642928-07-2 Homo sildenafil AKSci Y0495
 
 
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  Y0495    
Homo sildenafil, 98%
 
5-[2-Ethoxy-5-[(4-ethyl-1-piperazinyl)sulfonyl]phenyl]-1,6-dihydro-1-methyl-3-propyl-7H-pyrazolo[4,3-d]pyrimidin-7-one
IDENTITY
CAS Number:642928-07-2
MDL Number:MFCD09752148
MF:C23H32N6O4S
MW:488.6
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:98%
Physical Form (at 20°C):Solid
Melting Point:192-194°C
Density:1.4
Refractive Index:1.65
Long-Term Storage:Store long-term at -20°C
DOT/IATA TRANSPORT INFORMATION
Not hazardous material

BIOLOGICAL INFO
Solubility:Soluble in Chloroform, Dichloromethane and Methanol
Application(s):A new analog of sildenafil

REVIEW
 Homo Sildenafil is a new analog of Sildenafil. Sildenafil is a selective inhibitor of the type 5 cGMP phosphodiesterase (PDE5 inhibitor) which catalyzes the hydrolysis of 3'',5''-cyclic guanosine monophosphate (cGMP). As a PDE5 inhibitor, Sildenafil has been reported to enhance neuro-, synapto- and angiogenesis in rat models of stroke and also is reported to be a mild vasodilator. Sildenafil has also been shown to prevent indomethacin-induced small intestinal ulceration formation through an NO/cGMP- dependent mechanism.

REFERENCES
[1]Koh, H.L. and Woo, S.O. 2000. Drug Saf. 23: 351-362. PMID: 11085343
[2] Seftel, A.D. 2004. Clin Cardiol. 27: I14-I19. PMID: 15115191
[3] Bednar, M.M. 2008. Curr Opin Investig Drugs. 9: 754-759. PMID: 18600581
[4] Kato, N., et al. 2009. Dig. Dis. Sci. 54: 2346-2356. PMID: 19101800

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Warning

Hazard Statements
H315; H319; H335

Precautionary Statements
P261; P264; P271; P280; P302+P352; P304+P340; P305+P351+P338; P312; P321; P332+P313; P337+P313; P362; P403+P233; P405; P501

RELATED PRODUCTS
E241Sildenafil citrate
M901Sildenafil
Y0495Homo sildenafil

Current as of September 15, 2024


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CATEGORIES
 APIs and Bioactives > PDE5 Inhibitors


PubChem