Soluble in Chloroform, Dichloromethane and Methanol
A new analog of sildenafil
REVIEW Homo Sildenafil is a new analog of Sildenafil. Sildenafil is a selective inhibitor of the type 5 cGMP phosphodiesterase (PDE5 inhibitor) which catalyzes the hydrolysis of 3'',5''-cyclic guanosine monophosphate (cGMP). As a PDE5 inhibitor, Sildenafil has been reported to enhance neuro-, synapto- and angiogenesis in rat models of stroke and also is reported to be a mild vasodilator. Sildenafil has also been shown to prevent indomethacin-induced small intestinal ulceration formation through an NO/cGMP- dependent mechanism.
Koh, H.L. and Woo, S.O. 2000. Drug Saf. 23: 351-362. PMID: 11085343
Seftel, A.D. 2004. Clin Cardiol. 27: I14-I19. PMID: 15115191
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