139755-83-2 Sildenafil AKSci M901
 
 
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  M901    
Sildenafil
, 98% (HPLC)
 



IDENTITY
CAS Number:139755-83-2
MDL Number:MFCD00867528
MF:C22H30N6O4S
MW:474.58
SPECIFICATIONS & PROPERTIES
Purity:98% (HPLC)
Spectra:LCMS, HPLC
Physical Form:White to off-white powder
Melting Point:186-189°C
Density:1.4
Refractive Index:1.66
Long-Term Storage:Store long-term at 2-8°C
UN #:Not hazmat

BIOLOGICAL INFO
Application(s):Vasodilator Agent; Selective cGMP-specific phosphodiesterase type 5 (PDE5) Inhibitor
Form:Free Base

REVIEW

 A selective inhibitor of cGMP specific phosphodiesterase type 5 (PDE5). Sildenafil is used to treat erectile dysfunction and pulmonary arterial hypertension.

REFERENCES
[1]Percival JM, Whitehead NP, Adams ME, Adamo CM, Beavo JA, Froehner SC (2012). Sildenafil reduces respiratory muscle weakness and fibrosis in the mdx mouse model of Duchenne muscular dystrophy. J Pathol. 228(1):77-87. PMID 22653783.
[2] Hollatz TJ, Musat A, Westphal S, Decker C, D'Alessandro AM, Keevil J, Zhanhai L, Runo JR (2012). Treatment with sildenafil and treprostinil allows successful liver transplantation of patients with moderate to severe portopulmonary hypertension. Liver Transpl. 18(6):686-95. PMID 22315210.

GHS

Pictograms

Signal Word
Warning

Hazard Statements
H315; H319; H335

Precautionary Statements
P261; P264; P271; P280; P302+P352; P304+P340; P305+P351+P338; P312; P321; P332+P313; P337+P313; P362; P403+P233; P405; P501


RELATED PRODUCTS
E241Sildenafil citrate
M901Sildenafil
Y0495Homo sildenafil

Current as of January 18, 2019


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CATEGORIES

 APIs and Bioactives > PDE5 Inhibitors


PubChem