139755-83-2 Sildenafil AKSci M901
 
 
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  M901    AKSci Reference Standard
Sildenafil, 98% (HPLC)
 



IDENTITY
CAS Number:139755-83-2
MDL Number:MFCD00867528
MF:C22H30N6O4S
MW:474.58
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:98% (HPLC)
Physical Form (at 20°C):Solid
Melting Point:186-189°C
Density:1.4
Refractive Index:1.66
Long-Term Storage:Store long-term in a cool, dry place
DOT/IATA TRANSPORT INFORMATION
Not hazardous material

BIOLOGICAL INFO
Application(s):Vasodilator Agent; Selective cGMP-specific phosphodiesterase type 5 (PDE5) Inhibitor
Form:Free Base

REVIEW
 A selective inhibitor of cGMP specific phosphodiesterase type 5 (PDE5). Sildenafil is used to treat erectile dysfunction and pulmonary arterial hypertension.

REFERENCES
[1]Percival JM, Whitehead NP, Adams ME, Adamo CM, Beavo JA, Froehner SC (2012). Sildenafil reduces respiratory muscle weakness and fibrosis in the mdx mouse model of Duchenne muscular dystrophy. J Pathol. 228(1):77-87. PMID 22653783.
[2] Hollatz TJ, Musat A, Westphal S, Decker C, D'Alessandro AM, Keevil J, Zhanhai L, Runo JR (2012). Treatment with sildenafil and treprostinil allows successful liver transplantation of patients with moderate to severe portopulmonary hypertension. Liver Transpl. 18(6):686-95. PMID 22315210.

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Warning

Hazard Statements
H315; H319; H335

Precautionary Statements
P261; P264; P271; P280; P302+P352; P304+P340; P305+P351+P338; P312; P321; P332+P313; P337+P313; P362; P403+P233; P405; P501

RELATED PRODUCTS
E241Sildenafil citrate
M901Sildenafil
Y0495Homo sildenafil

Current as of March 29, 2023

AKSci Reference Standards are high-purity, low-impurity compounds suitable for use as standards.


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CATEGORIES
 APIs and Bioactives > PDE5 Inhibitors


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