REVIEW Cefodizime is a third generation cephalosporin beta lactam with a broad spectrum of antibacterial activity and immunomodulating activity, and used in the treatment of otitis media, sinusitis and gynaecological infections, and for the prophylaxis or treatment of surgical infections. Cefodizime inhibits bacterial cell wall synthesis by binding to one or more of the penicillin-binding proteins (PBPs). This inhibits the final transpeptidation step of peptidoglycan synthesis in bacterial cell walls, thus inhibiting cell wall biosynthesis. Bacteria eventually lyse due to ongoing activity of cell wall autolytic enzymes (autolysins and murein hydrolases) while cell wall assembly is arrested.Cefotaxime sodium is used in combination with sulbactam sodium, a beta-lactamase inhibitor for use as an injectable. The sulbactam sodium inhibiting beta-lactamase, which would otherwise deactivate the cefodizime.
REFERENCES
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Le Noc P; Bryskier A; Le Noc D In vitro antibacterial activity of cefodizime (HR 221) on 323 hospital strains of Gram negative bacilli. Comparison with cefotiam, cefoperazone, cefotetan and cefotaxime Pathologie-biologie (1985), 33(5), 399-403.
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Blumbach J, Dürckheimer W, Ehlers E, Fleischmann K, Klesel N, Limbert M, Mencke B, Reden J, Scheunemann KH, Schrinner E. Cefodizime, an aminothiazolylcephalosporin. V. Synthesis and structure-activity relationships in the cefodizime series. J Antibiot (Tokyo). 1987 Jan;40(1) 29-42. PMID: 3558116.
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Jaenicke, Ottmar; Wagner, Hans; Worm, Manfred Procedure for the preparation of cefodizime Ger. Offen. (1987), DE 3542644 A1 19870604.
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Labro MTCefodizime as a biological response modifier: a review of its in-vivo, ex-vivo and in-vitro immunomodulatory properties. J Antimicrob Chemother. 1990 Nov;26 Suppl C:37-47.
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