Vasodilator Agent; Selective cGMP-specific phosphodiesterase type 5 (PDE5) Inhibitor
REVIEW A selective inhibitor of cGMP specific phosphodiesterase type 5 (PDE5). Sildenafil is used to treat erectile dysfunction and pulmonary arterial hypertension.
Percival JM, Whitehead NP, Adams ME, Adamo CM, Beavo JA, Froehner SC (2012). Sildenafil reduces respiratory muscle weakness and fibrosis in the mdx mouse model of Duchenne muscular dystrophy. J Pathol. 228(1):77-87. PMID 22653783.
Hollatz TJ, Musat A, Westphal S, Decker C, D'Alessandro AM, Keevil J, Zhanhai L, Runo JR (2012). Treatment with sildenafil and treprostinil allows successful liver transplantation of patients with moderate to severe portopulmonary hypertension. Liver Transpl. 18(6):686-95. PMID 22315210.
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