1-[4-[[2-(1-Methylethoxy)ethoxy]methyl]phenoxy]-3-[(1-methylethyl)amino]-2-propanol hemifumarate salt
IDENTITY
CAS Number:
104344-23-2
MDL Number:
MFCD00792743
MF:
2C18H31NO4.C4H4O4
MW:
766.96
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:
98% (GC)
Physical Form (at 20°C):
Solid
Melting Point:
99-105°C
Long-Term Storage:
Store long-term in a cool, dry place
DOT/IATA TRANSPORT INFORMATION
Not hazardous material
BIOLOGICAL INFO
Solubility:
DMSO: >20mg/mL
Application(s):
Selective beta-1 adrenergic receptor antagonist
Form:
Fumarate salt
REVIEW Bisoprolol selectively blocks catecholamine stimulation of beta1-adrenergic receptors in the heart and vascular smooth muscle. This results in a reduction of heart rate, cardiac output, systolic and diastolic blood pressure, and possibly reflex orthostatic hypotension. At higher doses (e.g. 20 mg and greater) bisoprolol may competitively block beta2-adrenergic receptors in bronchial and vascular smooth muscle causing bronchospasm and vasodilation.
REFERENCES
[1]
Amabile, G.; Serradimigni, A. (1987). Comparison of bisoprolol with nifedipine for treatment of essential hypertension in the elderly: Comparative double-blind trial. European heart journal 8 Suppl M: 65-69. PMID 2967187. edit
[2]
Thadani, U. (2004). Current medical management of chronic stable angina. Journal of cardiovascular pharmacology and therapeutics 9 Suppl 1: S11-S29; quiz S29-9. PMID 15378129. edit
[3]
Konishi, M.; Haraguchi, G.; Kimura, S.; Inagaki, H.; Kawabata, M.; Hachiya, H.; Hirao, K.; Isobe, M. (2010). Comparative effects of carvedilol vs bisoprolol for severe congestive heart failure. Circulation journal : official journal of the Japanese Circulation Society 74 (6): 1127-1134. PMID 20354334. edit
[4]
Haeusler G, Schliep HJ, Schelling P, et al. (1986). High beta 1-selectivity and favourable pharmacokinetics as the outstanding properties of bisoprolol. J. Cardiovasc. Pharmacol. 8 Suppl 11: S2-15. PMID 2439793.
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