104344-23-2 Bisoprolol hemifumarate AKSci G646
 
 
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  G646    AKSci Reference Standard
Bisoprolol hemifumarate
, 98% (GC)
 
1-[4-[[2-(1-Methylethoxy)ethoxy]methyl]phenoxy]-3-[(1-methylethyl)amino]-2-propanol hemifumarate salt




IDENTITY
CAS Number:104344-23-2
MDL Number:MFCD00792743
MF:2C18H31NO4.C4H4O4
MW:766.96
SPECIFICATIONS & PROPERTIES
Purity:98% (GC)
Spectra:FT-IR, GC
Physical Form:White to off-white powder or crystalline powder
Melting Point:99-105°C
Long-Term Storage:Store at room temperature

BIOLOGICAL INFO
Solubility:DMSO: >20mg/mL
Application(s):Selective beta-1 adrenergic receptor antagonist
Form:Fumarate salt

REVIEW

 Bisoprolol selectively blocks catecholamine stimulation of beta1-adrenergic receptors in the heart and vascular smooth muscle. This results in a reduction of heart rate, cardiac output, systolic and diastolic blood pressure, and possibly reflex orthostatic hypotension. At higher doses (e.g. 20 mg and greater) bisoprolol may competitively block beta2-adrenergic receptors in bronchial and vascular smooth muscle causing bronchospasm and vasodilation.

REFERENCES
[1]Amabile, G.; Serradimigni, A. (1987). Comparison of bisoprolol with nifedipine for treatment of essential hypertension in the elderly: Comparative double-blind trial. European heart journal 8 Suppl M: 65-69. PMID 2967187. edit
[2] Thadani, U. (2004). Current medical management of chronic stable angina. Journal of cardiovascular pharmacology and therapeutics 9 Suppl 1: S11-S29; quiz S29-9. PMID 15378129. edit
[3] Konishi, M.; Haraguchi, G.; Kimura, S.; Inagaki, H.; Kawabata, M.; Hachiya, H.; Hirao, K.; Isobe, M. (2010). Comparative effects of carvedilol vs bisoprolol for severe congestive heart failure. Circulation journal : official journal of the Japanese Circulation Society 74 (6): 1127-1134. PMID 20354334. edit
[4] Haeusler G, Schliep HJ, Schelling P, et al. (1986). High beta 1-selectivity and favourable pharmacokinetics as the outstanding properties of bisoprolol. J. Cardiovasc. Pharmacol. 8 Suppl 11: S2-15. PMID 2439793.

GHS

Pictograms

Signal Word
Warning

Hazard Statements
H302

Precautionary Statements
P264; P270; P301+P312; P330; P501


RELATED PRODUCTS
G646Bisoprolol hemifumarate
K094Bisoprolol

Current as of July 7, 2020

AKSci Reference Standards are high-purity, low-impurity compounds suitable for use as standards.


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CATEGORIES

 APIs and Bioactives > Beta Blockers


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