REVIEW Plerixafor octahydrochloride is a selective bicyclam derivative which functions as a stem cell mobiliser via blocking the CXCR4 chemokine receptor. Studies suggest that it causes the rapid movement of stem cells out of bone marrow via blocking the CXCR4 receptor. Since the CXCR4 receptor is responsible for regulating metastasis in chemoresistant melanoma cells, blocking this receptor can possibly reduce the metastasis of melanoma cells. In addition, studies indicate that plerixafor octahydrochloride can inhibit the replication of human immunodeficiency virus in vitro by blocking the entry of the virus into cells. Furthermore, plerixafor octahydrochloride can also reduce the number of human CD4+ T cells.
Datema, R., et al., 1996. Antiviral efficacy in vivo of the anti-human immunodeficiency virus bicyclam SDZ SID 791 (JM 3100), an inhibitor of infectious cell entry. Antimicrobial agents and chemotherapy. 40(3): 750-4. PMID: 8851605
Kim, Minah., et al., 2010. CXCR4 signaling regulates metastasis of chemoresistant melanoma cells by a lymphatic metastatic niche. Cancer research. 70(24): 10411-21. PMID: 21056990