1391063-17-4 4-(3,5-Dichloro-4-methoxyanilino)-6-methoxy-7-[3-(4-methylpiperazin-1-yl)propoxy]quinoline-3-carbonitrile AKSci X4840
 
 
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  X4840    
4-(3,5-Dichloro-4-methoxyanilino)-6-methoxy-7-[3-(4-methylpiperazin-1-yl)propoxy]quinoline-3-carbonitrile
, 98%
 
Bosutinib Isomer




IDENTITY
CAS Number:1391063-17-4
MDL Number:MFCD22418831
MF:C26H29Cl2N5O3
MW:530.45
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:98%
Physical Form (at 20°C):Solid
Long-Term Storage:Store long-term in a cool, dry place
Note:This Bosutinib Isomer differs only in the positions of the chlorines and methoxy substituents on the aniline ring. Often mistaken to be the correct structure of bosutinib.
DOT/IATA TRANSPORT INFORMATION
Not hazardous material

REVIEW

 Isomer of Bostinub (also known as SK1-606) , a tyrosine kinase inhibitor, undergoing research for use in the treatment of cancer. originally synthesized by Wyeth, it is being developed by Pfizer. Bosutinib received US FDA approval on September 4, 2012 for the treatment of adult patients with chronic, accelerated, or blast phase Philadelphia chromosome-positive (Ph+) chronic myelogenous leukemia (CML) with resistance, or intolerance to prior therapy.

REFERENCES
[1]Vultur A, Buettner R, Kowolik C, Liang W, Smith D, Boschelli F, Jove R. SKI-606 (bosutinib), a novel Src kinase inhibitor, suppresses migration and invasion of human breast cancer cells. Mol Cancer Ther. 2008 May;7(5):1185-94.
[2] Cortes JE, Kantarjian HM, BrCimmendorf TH, Kim DW, Turkina AG, Shen ZX, Pasquini R, Khoury Hi, Arkin S, Volkert A, Besson N, Abbas R, Wang J, Leip E, Gambacorti-Passerini C. Safety and efficacy of bosutinib (SKI-606) in chronic phase Philadelphia chromosome-positive chronic myeloid leukemia patients with resistance or intolerance to imatinib. Blood. 2011 Oct 27418(17):4567-76.

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Warning

Hazard Statements
H315; H319; H335

Precautionary Statements
P261; P264; P271; P280; P302+P352; P304+P340; P305+P351+P338; P312; P321; P332+P313; P337+P313; P362; P403+P233; P405; P501


RELATED PRODUCTS
A820Bosutinib
X48404-(3,5-Dichloro-4-methoxyanilino)-6-methoxy-7-[3-(4-methylpiperazin-1-yl)propoxy]quinoline-3-carbonitrile

Current as of March 29, 2023


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