486460-32-6 Sitagliptin AKSci X4663
 
 
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  X4663    AKSci Bulk Reagent
Sitagliptin, >98% (HPLC), powder
 
Januvia
Xelevia
Sitagliptan
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IDENTITY
CAS Number:486460-32-6
MDL Number:MFCD09838015
MF:C16H15F6N5O
MW:407.32
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:>98% (HPLC), powder
Physical Form (at 20°C):Solid
Melting Point:110-120°C
Long-Term Storage:Store long-term in a cool, dry place
DOT/IATA TRANSPORT INFORMATION
Not hazardous material

BIOLOGICAL INFO
Application(s):Inhibitor of DPP-IV

REVIEW
 Sitagliptin is an orally available hypoglycemic (anti-diabetic drug) of the dipeptidyl peptidase-4 (DPP-4) inhibitor class of drugs. This enzyme-inhibiting drug is to be used either alone or in combination with metformin or a thiazolidinedione for control of type 2 diabetes mellitus. It is for use as an adjunct to diet and exercise to improve glycemic control in patients with type 2 diabetes mellitus.

REFERENCES
[1]Sorbera, L. A.; Castaner, J. MK-0431: agent for type 2 diabetes and dipeptidyl-peptidase IV (CD26) inhibitor. Drugs of the Future. (2005) 30(4): 337-343.
[2] Bardsley, Joan K.; Ratner, Robert E.Sitagliptin: an oral agent for glucose control Expert Review of Endocrinology & Metabolism (2008), 3(6), 691-697.
[3] Dhillon, Sohita. Sitagliptin: a review of its use in the management of type 2 diabetes mellitus. Drugs. (2010) 70(4): 489-512.
[4] Edmondson, Scott D.; Fisher, Michael H.; Kim, Dooseop; MacCoss, Malcolm; Parmee, Emma R.; Weber, Ann E.; Xu, Jinyou Preparation of beta-amino tetrahydroimidazo[1,2-a]pyrazines and tetrahydrotrioazolo[4,3-a]pyrazines as dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes PCT Int. Appl. (2003), WO 2003004498 A1 20030116.

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Warning

Hazard Statements
H315; H319; H335

Precautionary Statements
P261; P264; P271; P280; P302+P352; P304+P340; P305+P351+P338; P312; P321; P332+P313; P337+P313; P362; P403+P233; P405; P501

RELATED PRODUCTS
S053Sitagliptin phosphate
X4663Sitagliptin
X0051Sitagliptin phosphate monohydrate

Current as of December 4, 2024


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