REVIEW Rebaudioside-A is a steviol glycoside responsible for the sweet taste of the leaves of the stevia plant. These compounds range in sweetness from 300 times sweeter than sucrose. Rebaudioside-A is heat-stable, pH-stable, does not ferment, and does not induce a glycemic response when ingested, thus making them attractive as natural sweeteners to diabetics and others on carbohydrate-controlled diets. It has recently been shown potently stimulates the insulin secretion, and this insulinotropic effect of rebaudioside-A has been shown to be mediated via inhibition of ATP-sensitive K(+)-channels and requires the presence of high glucose.
REFERENCES
[1]
Kaneda, Norito; Kasai, Ryoji; Yamasaki, Kazuo; Tanaka, Osamu. Chemical studies on sweet diterpene-glycosides of Stevia rebaudiana: conversion of stevioside into Rebaudioside A. Chemical & Pharmaceutical Bulletin. (1977) 25(9): 2466-7.
[2]
Kim, Darrick S. H. L. Synthetic investigations on steviol, stevioside, and rebaudioside A, and their applications as starting materials. Medicinal and Aromatic Plants--Industrial Profiles. (2002) 19(Stevia): 119-137.
[3]
Abudula R, Matchkov VV, Jeppesen PB, Nilsson H, Aalkjaer C, Hermansen K. Rebaudioside A directly stimulates insulin secretion from pancreatic beta cells: a glucose-dependent action via inhibition of ATP-sensitive K-channels. Diabetes Obes Metab. (2008) Nov;10(11): 1074-85.
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