538-09-0 Nortropine AKSci W6811
 
 
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  W6811    
Nortropine
, 99% (GC)
 
1-alpha-H,5-alpha-H-Nortropan-3-alpha-ol




IDENTITY
CAS Number:538-09-0
MDL Number:MFCD00047140
MF:C7H13NO
MW:127.18
BRN:1633758
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:99% (GC)
Spectra:GCMS, FT-IR, GC
Physical Form:White to beige to pale reddish-yellow powder
Melting Point:159-164°C
Boiling Point:267°C
Flash Point:115°C
Long-Term Storage:Store long-term in a cool, dry place
HAZARDOUS MATERIALS INFORMATION
Not hazardous material

REVIEW

 Nortropine is an example of a tropine alkaloid which are secondary metabolites of Solanaceae plants sharing a tropane skeleton as a common structural feature. The tropine alkaloids are considered to be model anticholinergic drugs (cholinergic antagonists), and continue to provide inspiration in the search for more selective muscarinic receptor antagonists. The compound is also used a bicyclic amino alcohol as a building block or linker in drug discovery for a wide range of targets and therapeutic areas.

REFERENCES
[1]Minatoya H. Hypotensive activity of nortropine and norpseudotropine substituted phenothiazines in hypertensive and normotensive animals. Arch Int Pharmacodyn Ther. 1963 Sep 1;145:97-108.
[2] Banholzer, R.; Pook, K. H.; Stiasni, M. Synthesis of the bronchospasmolytic agent flutropium bromide and of some homologous and configuration isomeric compounds. Arzneimittel-Forschung (1986), 36(8), 1161-6.
[3] Scheiber P, Kreiss G, Nádor K Tropine derivatives with central activities. Part II: Solvolysis of N-substituted nortropine methanesulfonates. Arzneimittelforschung. 1976;26(10):1797-800.
[4] Fulvio Gualtieri , Claudia Bottalico , Anna Calandrella , Silvia Dei , Maria Paola Giovannoni , Stefania Mealli , Maria Novella Romanelli , Serena Scapecchi , Elisabetta Teodori, Presynaptic Cholinergic Modulators as Potent Cognition Enhancers and Analgesic Drugs. 2. 2-Phenoxy-, 2-(Phenylthio)-, and 2-(Phenylamino)alkanoic Acid Esters Journal of Medicinal Chemistry (1994), 37(11), 1712-19.

GHS

Pictograms

Signal Word
Warning

Hazard Statements
H302

Precautionary Statements
P270; P264; P301+P312+P330; P330; P501;


RELATED PRODUCTS
W6811Nortropine
V0900Nortropine HCl

Current as of June 23, 2021


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CATEGORIES

 APIs and Bioactives > Alkaloids


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