136777-48-5, 188062-50-2 Abacavir sulphate AKSci V2105
 
 
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  V2105    AKSci Reference Standard
Abacavir sulphate
, 98% (HPLC)
 
ABC, Abacavir Hemisulfate, Ziagen




IDENTITY
CAS Number:136777-48-5, 188062-50-2
MDL Number:MFCD04112763
MF:C28H38N12O6S
MW:670.74
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:98% (HPLC)
Physical Form (at 20°C):Solid
Melting Point:232-237°C
Long-Term Storage:Store long-term at 2-8°C
DOT/IATA TRANSPORT INFORMATION
Not hazardous material

BIOLOGICAL INFO
Solubility:H2O: =17 mg/mL; soluble in DMSO, MeOH.
Application(s):Reverse transcriptase inhibitor (NRTI)
Form:Slufate salt

REVIEW

 Abacavir sulfate is a Nucleoside analog reverse transcriptase inhibitor (NRTI); guanosine analog used to treat HIV and AIDS.

REFERENCES
[1]Mallal S, Phillips E, Carosi G et al. (February 2008). HLA-B*5701 screening for hypersensitivity to abacavir. N. Engl. J. Med. 358 (6): 568-79.
[2] Mallal S, Nolan D, Witt C et al. (2002). Association between the presence of HLA-B*5701, HLA-DR7 and HLA-DQ3 and hypersensitivity to HIV-1 reverse transcriptase inhibitor abacavir. Lancet 359 (9308): 727-32.
[3] Zucman D, de Truchis P, Majerholc C et al. (2007). Prospective Screening for Human Leukocyte Antigen-B*5701 Avoids Abacavir Hypersensitivity Reaction in the Ethnically Mixed French HIV Population. J Acquir Immune Defic Syndr 45 (1): 1-3.
[4] Rauch A, Nolan D, Martin A et al. (2006). Prospective genetic screening decreases the incidence of abacavir hypersensitivity reactions in the Western Australian HIV cohort study. Clin Infect Dis 43 (1): 99-102.

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Warning

Hazard Statements
H315; H319; H335

Precautionary Statements
P261; P264; P271; P280; P302+P352; P304+P340; P305+P351+P338; P312; P321; P332+P313; P337+P313; P362; P403+P233; P405; P501


RELATED PRODUCTS
V2105Abacavir sulphate
G906Abacavir

Current as of June 27, 2022

AKSci Reference Standards are high-purity, low-impurity compounds suitable for use as standards.


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CATEGORIES

 APIs and Bioactives > Antivirals, Antiretrovirals, NRTIs


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