341031-54-7 Sunitinib malate AKSci V2095
 
 
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  V2095    
Sunitinib malate, 99% (HPLC), powder
 
Sunitinib
Sutent
IDENTITY
CAS Number:341031-54-7
MDL Number:MFCD08282795
MF:C26H33FN4O7
MW:532.56
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:99% (HPLC), powder
Physical Form (at 20°C):Solid
Melting Point:225-238°C
Long-Term Storage:Store long-term at 2-8°C
DOT/IATA TRANSPORT INFORMATION
Not hazardous material

BIOLOGICAL INFO
Application(s):Multi-targeted receptor tyrosine kinase (RTK) inhibitor
Form:Malate salt

REVIEW
 Sutent (sunitinib malate) an oral multi-kinase inhibitor and works by blocking multiple molecular targets implicated in the growth, proliferation and spread of cancer. Two Sutent targets, vascular endothelial growth factor receptor (VEGFR) and platelet-derived growth factor receptor (PDGFR), are expressed by many types of solid tumors and are thought to play a crucial role in angiogenesis, the process by which tumors acquire blood vessels, oxygen and nutrients needed for growth. Sutent also inhibits other targets important to tumor growth, including KIT, FLT3 and RET.

REFERENCES
[1]Raymond E, Dahan L, Raoul JL, Bang YJ, Borbath I, Lombard-Bohas C, Valle J, Metrakos P, Smith D, Vinik A, Chen JS, Hörsch D, Hammel P, Wiedenmann B, Van Cutsem E, Patyna S, Lu DR, Blanckmeister C, Chao R, Ruszniewski P Sunitinib malate for the treatment of pancreatic neuroendocrine tumors. The New England Journal of Medicine 2011 Feb 10;364(6):501-13
[2] O'Reilly EM, Niedzwiecki D, Hall M, Hollis D, Bekaii-Saab T, Pluard T, Douglas K, Abou-Alfa GK, Kindler HL, Schilsky RL, Goldberg RM; Cancer and Leukemia Group B A Cancer and Leukemia Group B phase II study of sunitinib malate in patients with previously treated metastatic pancreatic adenocarcinoma (CALGB 80603). The Oncologist 2010;15(12):1310-9. Epub 2010 Dec 10

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Danger

Hazard Statements
H360; H372

Precautionary Statements
P201; P202; P260; P264; P270; P281; P308+P313; P405; P501

RELATED PRODUCTS
V2095Sunitinib malate
L781Sunitinib, Free base

Current as of April 25, 2024


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CATEGORIES
 APIs and Bioactives > Protein Kinase Inhibitors


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