REVIEW Cefamandole is used to study antibiotic resistance, the effects of expression and inhibition of penicillin-binding proteins, and the cooperation of antibiotics with host defence mechanisms. Cefamandole is used to study the effects of expression and inhibition of PBP 2A and other penicillin-binding proteins (PDPs) on bacterial cell wall mucopeptide synthesis. Cefamandole, a cephalosporin antibiotic, disrupts the synthesis of the peptidoglycan layer of bacterial cell walls. As Cefamandole is broken down in the body, it releases free N-methylthiotetrazole, which can cause hypoprothrombinemia.
REFERENCES
[1]
Resistance to Cefamandole: Derepression of β-Lactamases by Cefoxitin and Mutation in Enterobacter cloacae. Thomas D. Gootz, Christine C. Sanders, et al. J. Infect. Dis. 146, 34-42, (1982)
[2]
Increased phagocytosis and killing of Escherichia coli treated with subinhibitory concentrations of cefamandole and gentamicin in isolated rat livers. A Andreana, P Perna, et al. Antimicrob. Agents Chemother. 25, 182-186, (1984)
[3]
Stork CM Antibiotics, Antifungals, and Antivirals, (2006), 847
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