6893-02-3 3,3',5-Triiodo-L-thyronine AKSci V0160
 
 
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  V0160    
3,3',5-Triiodo-L-thyronine
, 97% (HPLC)
 
Liothyronine




IDENTITY
CAS Number:6893-02-3
MDL Number:MFCD00002593
MF:C15H12I3NO4
MW:650.97
EINECS:229-999-3
BRN:2710227
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:97% (HPLC)
Physical Form (at 20°C):Solid
Melting Point:234-238°C
Optical Rotation:+21.0 to +25.0° (c=5, 1mol/L HCl:EtOH=1:2)
Long-Term Storage:Store long-term at -20°C
DOT/IATA TRANSPORT INFORMATION
Not hazardous material

REVIEW

 Using video intensification fluorescence microscopy and tetramethylrhodamine (Rho)-labeled 3, 3', 5-triiodo-L-thyronine (T3), the uptake of T3 by cultured mouse fibroblasts was studied. The binding of 3, 3', 5-triiodo-L-thyronine (T3) to GH3 rat pituitary tumor cells was studied at 15 degrees C and was shown to be saturable, reversible, and stereospecific. A fluorescent derivative of the thyroid hormone 3,3'-triiodo-L-thyronine binds to cultured mouse fibroblasts; such binding is saturable. 3,3?,5-Triiodo-L-thyronine Up-regulation of Na,K-ATPase Activity and Cell Surface Expression in Alveolar Epithelial Cells Is Src Kinase- and Phosphoinositide 3-Kinase-dependent.

REFERENCES
[1]R Horiuchi,; M L Johnson,; M C Willingham,; I Pastan,; S Cheng. Affinity labeling of the plasma membrane 3,3',5-triiodo-L-thyronine receptor in GH3 cells. PNAS. 1982 , 79(18),5527-5531.
[2] Jianxun Lei,; Cary N. Mariash.; David H. Ingbar. 3,3?,5-Triiodo-L-thyronine Up-regulation of Na,K-ATPase Activity and Cell Surface Expression in Alveolar Epithelial Cells Is Src Kinase- and Phosphoinositide 3-Kinase-dependent . Journal of Biological Chemistry. 2004 , 279 , 47589-47600.

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Warning

Hazard Statements
H315; H319; H335

Precautionary Statements
P261; P264; P271; P280; P302+P352; P304+P340; P305+P351+P338; P312; P321; P332+P313; P337+P313; P362; P403+P233; P405; P501


RELATED PRODUCTS
I9273,3',5-Triiodo-L-thyronine, sodium salt
V01603,3',5-Triiodo-L-thyronine

Current as of June 18, 2024


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