REVIEW Domperidone is an antidopaminergic drug used to suppress nausea and vomiting, as a prokinetic agent and for promoting lactation. Domperidone blocks the action of dopamine. It has strong affinities for the D2 and D3 dopamine receptors, which are found in the chemoreceptor trigger zone, located just outside the blood brain barrier, which, among others, regulates nausea and vomiting.
Wang D, Parkman HP, Jacobs MR, Mishra AK, Krynetskiy E, Obradovic Z (2012). DNA microarray SNP associations with clinical efficacy and side effects of domperidone treatment for gastroparesis. J Biomed Inform. 45(2):316-22. PMID 22179054.
'Secor JD, Kotha SR, Gurney TO, Patel RB, Kefauver NR, Gupta N, Morris AJ, Haley BE, Parinandi NL (2011). Novel lipid-soluble thiol-redox antioxidant and heavy metal chelator, N,N''-bis(2-mercaptoethyl)isophthalamide (NBMI) and phospholipase D-specific inhibitor, 5-fluoro-2-indolyl des-chlorohalopemide (FIPI) attenuate mercury-induced lipid signaling leading to protection against cytotoxicity in aortic endothelial cells. Int J Toxicol. 30(6):619-38. PMID 21994240.'
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