99497-03-7 Domperidone maleate AKSci S484
 
 
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  S484    AKSci Reference Standard
Domperidone maleate
, 98% (HPLC)
 



IDENTITY
CAS Number:99497-03-7
MDL Number:MFCD07370074
MF:C26H28ClN5O6
MW:541.98
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:98% (HPLC)
Physical Form (at 20°C):Solid
Melting Point:233-236°C
Long-Term Storage:Store long-term in a cool, dry place
DOT/IATA TRANSPORT INFORMATION
Not hazardous material

BIOLOGICAL INFO
Application(s):D2 dopamine receptor antagonist
Form:Maleate

REVIEW

 Domperidone is an antidopaminergic drug used to suppress nausea and vomiting, as a prokinetic agent and for promoting lactation. Domperidone blocks the action of dopamine. It has strong affinities for the D2 and D3 dopamine receptors, which are found in the chemoreceptor trigger zone, located just outside the blood brain barrier, which, among others, regulates nausea and vomiting.

REFERENCES
[1]Wang D, Parkman HP, Jacobs MR, Mishra AK, Krynetskiy E, Obradovic Z (2012). DNA microarray SNP associations with clinical efficacy and side effects of domperidone treatment for gastroparesis. J Biomed Inform. 45(2):316-22. PMID 22179054.
[2] 'Secor JD, Kotha SR, Gurney TO, Patel RB, Kefauver NR, Gupta N, Morris AJ, Haley BE, Parinandi NL (2011). Novel lipid-soluble thiol-redox antioxidant and heavy metal chelator, N,N''-bis(2-mercaptoethyl)isophthalamide (NBMI) and phospholipase D-specific inhibitor, 5-fluoro-2-indolyl des-chlorohalopemide (FIPI) attenuate mercury-induced lipid signaling leading to protection against cytotoxicity in aortic endothelial cells. Int J Toxicol. 30(6):619-38. PMID 21994240.'

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Warning

Hazard Statements
H315; H319; H335

Precautionary Statements
P261; P264; P271; P280; P302+P352; P304+P340; P305+P351+P338; P312; P321; P332+P313; P337+P313; P362; P403+P233; P405; P501


RELATED PRODUCTS
S484Domperidone maleate

Current as of September 29, 2022

AKSci Reference Standards are high-purity, low-impurity compounds suitable for use as standards.


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CATEGORIES

 APIs and Bioactives > Dopamine Antagonists


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