99497-03-7 Domperidone maleate AKSci S484
 
 
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  S484    AKSci Reference Standard
Domperidone maleate
, 98% (HPLC)
 



IDENTITY
CAS Number:99497-03-7
MDL Number:MFCD07370074
MF:C26H28ClN5O6
MW:541.98
SPECIFICATIONS & PROPERTIES
Purity:98% (HPLC)
Spectra:NMR, LCMS, HPLC
Physical Form:White to off-white powder
Melting Point:233-236°C
Long-Term Storage:Store at room temperature

BIOLOGICAL INFO
Application(s):D2 dopamine receptor antagonist
Form:Maleate

REVIEW

 Domperidone is an antidopaminergic drug used to suppress nausea and vomiting, as a prokinetic agent and for promoting lactation. Domperidone blocks the action of dopamine. It has strong affinities for the D2 and D3 dopamine receptors, which are found in the chemoreceptor trigger zone, located just outside the blood brain barrier, which, among others, regulates nausea and vomiting.

REFERENCES
[1]Wang D, Parkman HP, Jacobs MR, Mishra AK, Krynetskiy E, Obradovic Z (2012). DNA microarray SNP associations with clinical efficacy and side effects of domperidone treatment for gastroparesis. J Biomed Inform. 45(2):316-22. PMID 22179054.
[2] 'Secor JD, Kotha SR, Gurney TO, Patel RB, Kefauver NR, Gupta N, Morris AJ, Haley BE, Parinandi NL (2011). Novel lipid-soluble thiol-redox antioxidant and heavy metal chelator, N,N''-bis(2-mercaptoethyl)isophthalamide (NBMI) and phospholipase D-specific inhibitor, 5-fluoro-2-indolyl des-chlorohalopemide (FIPI) attenuate mercury-induced lipid signaling leading to protection against cytotoxicity in aortic endothelial cells. Int J Toxicol. 30(6):619-38. PMID 21994240.'

GHS

Pictograms

Signal Word
Warning

Hazard Statements
H315; H319; H335

Precautionary Statements
P261; P264; P271; P280; P302+P352; P304+P340; P305+P351+P338; P312; P321; P332+P313; P337+P313; P362; P403+P233; P405; P501


RELATED PRODUCTS
S484Domperidone maleate

Current as of August 23, 2019

AKSci Reference Standards are high-purity, low-impurity compounds suitable for use as standards.


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For research use only. Not for diagnostic or therapeutic use.
Not for human use.


CATEGORIES

 APIs and Bioactives > Dopamine Antagonists


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