198904-31-3 Atazanavir AKSci R133
 
 
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  R133    
Atazanavir
, 98% (HPLC)
 
Latazanavir
Zrivada
Reyataz
more..




IDENTITY
CAS Number:198904-31-3
MDL Number:MFCD08435966
MF:C38H52N6O7
MW:704.86
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:98% (HPLC)
Physical Form (at 20°C):Solid
Melting Point:203-209°C
Optical Rotation:-47° to -37° (c=1, EtOH)
Long-Term Storage:Store long-term at -20°C
DOT/IATA TRANSPORT INFORMATION
Not hazardous material

BIOLOGICAL INFO
Application(s):Anti-HIV Agent; HIV Protease Inhibitor
Form:Free Base

REVIEW

 Atazanavir selectively inhibits the virus-specific processing of viral Gag and Gag-Pol polyproteins in HIV-1 infected cells by binding to the active site of HIV-1 protease, thus preventing the formation of mature virions. Atazanavir is not active against HIV-2.

REFERENCES
[1]Croom KF, Dhillon S, Keam SJ: Atazanavir: a review of its use in the management of HIV-1 infection. Drugs. 2009 May 29;69(8):1107-40. doi: 10.2165/00003495-200969080-00009.
[2] von Hentig N: Atazanavir/ritonavir: a review of its use in HIV therapy. Drugs Today (Barc). 2008 Feb;44(2):103-32.
[3] Swainston Harrison T, Scott LJ: Atazanavir: a review of its use in the management of HIV infection. Drugs. 2005;65(16):2309-36.
[4] Le Tiec C, Barrail A, Goujard C, Taburet AM: Clinical pharmacokinetics and summary of efficacy and tolerability of atazanavir. Clin Pharmacokinet. 2005;44(10):1035-50.

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Warning

Hazard Statements
H315; H319; H335

Precautionary Statements
P261; P264; P271; P280; P302+P352; P304+P340; P305+P351+P338; P312; P321; P332+P313; P337+P313; P362; P403+P233; P405; P501


RELATED PRODUCTS
N349Atazanavir sulfate
R133Atazanavir

Current as of May 21, 2024


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CATEGORIES

 APIs and Bioactives > Antivirals, Antiretrovirals, HIV Protease Inhibitors


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