REVIEW Catharanthine base is one of the many vinca alkaloids present in Catharanthus roseus. Can be used as a starting material for the synthesis of the anti-tumor drugs vinblastine and vincristine. It also binds to tubulin, with interaction of the indole part of catharanthine being common to its more potent vinca counterparts,
Catharanthine inhibits nicotinic receptor mediated diaphragm contractions with IC50 of 59.6 uM. catharanthine . It has also shown to be an acetylcholineesterase receptor inhibitor and an voltage-operated calcium channels on vascular smooth muscle cells and cardiomyocytes. Catharanthine, was shown to stimulate release of amylase from pancreatic fragments and to cause extensive degranulation of pancreatic acinar cells with accumulation of membrane material in the Golgi region. It is indicated that catharanthine activates the physiological pathway controlling amylase release by causing a rise in cytoplasmic Ca2+.
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