231277-92-2 Lapatinib AKSci Q570
 
 
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  Q570    AKSci Reference Standard
Lapatinib, 98% (HPLC), powder
 
Tykerb
N-[3-chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[5-[(2-methylsulfonylethylamino)methyl]-2-furyl] quinazolin-4-amine
IDENTITY
CAS Number:231277-92-2
MDL Number:MFCD09264194
MF:C29H26ClFN4O4S
MW:581.06
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:98% (HPLC), powder
Spectra:LCMS, HPLC
Physical Form (at 20°C):Light yellow to yellow crystalline powder or powder
Melting Point:136-140°C
Long-Term Storage:Store long-term at -20°C
DOT/IATA TRANSPORT INFORMATION
Not hazardous material

BIOLOGICAL INFO
Application(s):Antineoplastic Agent; Protein Kinase Inhibitor
Form:Free base

REVIEW
 A dual tyrosine kinase inhibitor which interrupts the HER2/neu (ErbB-2) and epidermal growth factor receptor (EGFR) pathways

REFERENCES
[1]Blackwell KL, Burstein HJ, Storniolo AM, Rugo HS, Sledge G, Aktan G, Ellis C, Florance A, Vukelja S, Bischoff J, Baselga J, O''Shaughnessy J (2012). Overall survival benefit with lapatinib in combination with trastuzumab for patients with human epidermal growth factor receptor 2-positive metastatic breast cancer: final results from the EGF104900 Study. J Clin Oncol. 30(21):2585-92. PMID 22689807.
[2] Labonte MJ, Wilson PM, Yang D, Zhang W, Ladner RD, Ning Y, Gerger A, Bohanes PO, Benhaim L, El-Khoueiry R, El-Khoueiry A, Lenz HJ (2012). The Cyclin D1 (CCND1) A870G polymorphism predicts clinical outcome to lapatinib and capecitabine in HER2-positive metastatic breast cancer. Ann Oncol. 23(6):1455-64. PMID 21989330.

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Warning

Hazard Statements
H315; H319; H335

Precautionary Statements
P261; P264; P271; P280; P302+P352; P304+P340; P305+P351+P338; P312; P321; P332+P313; P337+P313; P362; P403+P233; P405; P501

RELATED PRODUCTS
Q570Lapatinib
A817Lapatinib ditosylate
B402Lapatinib ditosylate monohydrate
W46955-(4-((3-Chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)quinazolin-6-yl)furan-2-carbaldehyde
B644N-[3-Chloro-4-(3-fluorobenzyloxy)phenyl]-6-iodoquinazolin-4-amine
B6463-Chloro-4-(3-fluorobenzyloxy)aniline

Current as of December 8, 2021

AKSci Reference Standards are high-purity, low-impurity compounds suitable for use as standards.


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CATEGORIES
 APIs and Bioactives > Protein Kinase Inhibitors


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