231277-92-2 Lapatinib AKSci Q570
 
 
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  Q570    AKSci Bulk Reagent
Lapatinib, 98% (HPLC), powder
 
Tykerb
N-[3-chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[5-[(2-methylsulfonylethylamino)methyl]-2-furyl] quinazolin-4-amine
IDENTITY
CAS Number:231277-92-2
MDL Number:MFCD09264194
MF:C29H26ClFN4O4S
MW:581.06
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:98% (HPLC), powder
Physical Form (at 20°C):Solid
Melting Point:136-140°C
Long-Term Storage:Store long-term at -20°C
DOT/IATA TRANSPORT INFORMATION
Not hazardous material

BIOLOGICAL INFO
Application(s):Antineoplastic Agent; Protein Kinase Inhibitor
Form:Free base

REVIEW
 A dual tyrosine kinase inhibitor which interrupts the HER2/neu (ErbB-2) and epidermal growth factor receptor (EGFR) pathways

REFERENCES
[1]Blackwell KL, Burstein HJ, Storniolo AM, Rugo HS, Sledge G, Aktan G, Ellis C, Florance A, Vukelja S, Bischoff J, Baselga J, O''Shaughnessy J (2012). Overall survival benefit with lapatinib in combination with trastuzumab for patients with human epidermal growth factor receptor 2-positive metastatic breast cancer: final results from the EGF104900 Study. J Clin Oncol. 30(21):2585-92. PMID 22689807.
[2] Labonte MJ, Wilson PM, Yang D, Zhang W, Ladner RD, Ning Y, Gerger A, Bohanes PO, Benhaim L, El-Khoueiry R, El-Khoueiry A, Lenz HJ (2012). The Cyclin D1 (CCND1) A870G polymorphism predicts clinical outcome to lapatinib and capecitabine in HER2-positive metastatic breast cancer. Ann Oncol. 23(6):1455-64. PMID 21989330.

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Warning

Hazard Statements
H315; H319; H335

Precautionary Statements
P261; P264; P271; P280; P302+P352; P304+P340; P305+P351+P338; P312; P321; P332+P313; P337+P313; P362; P403+P233; P405; P501

RELATED PRODUCTS
Q570Lapatinib
A817Lapatinib ditosylate
B402Lapatinib ditosylate monohydrate
W46955-(4-((3-Chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)quinazolin-6-yl)furan-2-carbaldehyde
B644N-[3-Chloro-4-(3-fluorobenzyloxy)phenyl]-6-iodoquinazolin-4-amine
B6463-Chloro-4-(3-fluorobenzyloxy)aniline

Current as of October 6, 2022


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⚠️
These chemical products are for research and development use only. They are not for diagnostic, therapeutic, cosmetic, or human and animal uses. They are not sold to individuals. Additional restrictions may apply.
New customers undergo an internal onboarding process. As part of this process, new customers may be asked for more information.

CATEGORIES
 APIs and Bioactives > Protein Kinase Inhibitors


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