209216-23-9 Entecavir monohydrate AKSci P238
 
 
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  P238    
Entecavir monohydrate, 98% (HPLC)
 
Baraclude
IDENTITY
CAS Number:209216-23-9
MDL Number:MFCD09754448
MF:C12H15N5O3.H2O
MW:295.29
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:98% (HPLC)
Physical Form (at 20°C):Solid
Melting Point:>220°C
Optical Rotation:+10.8° (c=20mg/10ml of MeOH)
Long-Term Storage:Store long-term at 2-8°C
Note:Loss on drying max 5%
DOT/IATA TRANSPORT INFORMATION
Not hazardous material

BIOLOGICAL INFO
Solubility:DMSO: 59mg/mL; H2O: insoluble; EtOH: <1mg/mL
Application(s):Antiviral; Viral DNA Polymerase Inhibitor
Form:Hydrate

REVIEW
 Entecavir hydrate is an oral antiviral drug used in the treatment of hepatitis B infection. Entecavir hydrate is a nucleoside analog (more specifically, a guanine analogue) that inhibits reverse transcription, DNA replication and transcription in the viral replication process.

REFERENCES
[1]Wong GL, Wong VW, Chan HY, Tse PC, Wong J, Chim AM, Yiu KK, Chu SH, Chan HL (2012). Undetectable HBV DNA at month 12 of entecavir treatment predicts maintained viral suppression and HBeAg-seroconversion in chronic hepatitis B patients at 3 years. Aliment Pharmacol Ther. 35(11):1326-35. PMID 22506552.
[2] 'Pol S, Lampertico P (2012). First-line treatment of chronic hepatitis B with entecavir or tenofovir in ''real-life'' settings: from clinical trials to clinical practice. J Viral Hepat. 19(6):377-86. PMID 22571899. '

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Warning

Hazard Statements
H302

Precautionary Statements
P270; P264; P301+P312+P330; P330; P501;


RELATED PRODUCTS
G985Entecavir
P238Entecavir monohydrate

Current as of April 16, 2024


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CATEGORIES
 APIs and Bioactives > Antivirals;NRTIs


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