Soluble in water (24 mg/ml), DMSO (88 mg/ml at 25 °C), and ethanol (<1 mg/ml at 25 °C)
An 8-methoxy-fluoroquinolone antibacterial
REVIEW Moxifloxacin Hydrochloride is the hydrochloride salt preparation of Moxifloxacin, an 8-methoxy-fluoroquinone compound with broad-spectrum bactericidal activity against gram-positive and gram-negative strains. 8-methoxy-fluoroquinones are described to inhibit the activities of DNA gyrase and topoisomerase IV. The 8-methoxy group of Moxifloxacin is suggested to confer a lowered propensity for resistance development as compared to other C-8 substituted quinolones, and Moxifloxacin demonstrates potent activity against wild-type and first-step gyrase- and topoisomerase IV-resistant mutants. Moxifloxacin shows activity against methicillin-susceptible staphylococci, penicillin-susceptible and penicillin-resistant pneumococci, penicillin-susceptible and penicillin-resistant viridans group streptococci, group A streptococci, M. catarrhalis, and H. influenzae in vitro. IC50 data: Streptokinase A: EC5050 = 171 nM (Streptococcus pyogenes serotype M1); Streptococcus sp. ''group A'': EC5050 = 199 nM; DNA gyrase: IC50 = 300 nM (Escherichia coli K-12); Streptococcus: EC5050 = 358 nM; PhoP regulon: IC50 = 420 nM (Salmonella typhi).
Souli, M., et al. 1998. Int. J. Antimicrob. Agents. 10: 23-30. PMID: 9624540.