186826-86-8 Moxifloxacin HCl AKSci O381
 
 
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  O381    AKSci Bulk Reagent
Moxifloxacin HCl, 98% (HPLC)
 
1-Cyclopropyl-6-fluoro-8-methoxy-7-[(4aS,7aS)-octahydropyrrolo[3,4-b]pyridin-6-yl]-4-oxo-1,4-dihydroquinoline-3-carboxylic acid hydrochloride
IDENTITY
CAS Number:186826-86-8
MDL Number:MFCD00949117
MF:C21H25ClFN3O4
MW:437.89
BRN:8377447
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:98% (HPLC)
Physical Form (at 20°C):Solid
Melting Point:247-250°C
Boiling Point:636°C
Flash Point:>110°C
Optical Rotation:-125,0 – 138.0° (c=0.5, H2O)
Long-Term Storage:Store long-term at 2-8°C
DOT/IATA TRANSPORT INFORMATION
Not hazardous material

BIOLOGICAL INFO
Solubility:Soluble in water (24 mg/ml), DMSO (88 mg/ml at 25 °C), and ethanol (<1 mg/ml at 25 °C)
Application(s):An 8-methoxy-fluoroquinolone antibacterial
Form:HCl salt

REVIEW
 Moxifloxacin Hydrochloride is the hydrochloride salt preparation of Moxifloxacin, an 8-methoxy-fluoroquinone compound with broad-spectrum bactericidal activity against gram-positive and gram-negative strains. 8-methoxy-fluoroquinones are described to inhibit the activities of DNA gyrase and topoisomerase IV. The 8-methoxy group of Moxifloxacin is suggested to confer a lowered propensity for resistance development as compared to other C-8 substituted quinolones, and Moxifloxacin demonstrates potent activity against wild-type and first-step gyrase- and topoisomerase IV-resistant mutants. Moxifloxacin shows activity against methicillin-susceptible staphylococci, penicillin-susceptible and penicillin-resistant pneumococci, penicillin-susceptible and penicillin-resistant viridans group streptococci, group A streptococci, M. catarrhalis, and H. influenzae in vitro. IC50 data: Streptokinase A: EC5050 = 171 nM (Streptococcus pyogenes serotype M1); Streptococcus sp. ''group A'': EC5050 = 199 nM; DNA gyrase: IC50 = 300 nM (Escherichia coli K-12); Streptococcus: EC5050 = 358 nM; PhoP regulon: IC50 = 420 nM (Salmonella typhi).

REFERENCES
[1]Souli, M., et al. 1998. Int. J. Antimicrob. Agents. 10: 23-30. PMID: 9624540.
[2] Ballow, C., et al. 1999. Clin Ther. 21: 513-522. PMID: 10321420.
[3] Dalhoff, A., 2001. Clin. Infect. Dis. 32: S16-S22. PMID: 11249824.
[4] Dalhoff, A., et al. 2001. Clin. Infect. Dis. 32: S22-S29. PMID: 11249825.

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Warning

Hazard Statements
H315; H319; H335

Precautionary Statements
P261; P264; P271; P280; P302+P352; P304+P340; P305+P351+P338; P312; P321; P332+P313; P337+P313; P362; P403+P233; P405; P501

RELATED PRODUCTS
O381Moxifloxacin HCl
E111Moxifloxacin

Current as of April 19, 2024


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