57149-07-2 Naftopidil AKSci O220
 
 
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  O220    
Naftopidil
, 98% (HPLC)
 
1-[4-(2-Methoxyphenyl)piperazinyl]-3-(1-naphthyloxy)propan-2-ol




IDENTITY
CAS Number:57149-07-2
MDL Number:MFCD00242741
MF:C24H28N2O3
MW:392.49
SPECIFICATIONS & PROPERTIES
Purity:98% (HPLC)
Physical Form:White powder
Melting Point:125-129°C
Long-Term Storage:Store at room temperature

BIOLOGICAL INFO
Form:Free Base
Research Area:cardiovascular disease

REVIEW

 Naftopidil (Flivas) is an selective alpha1-adrenergic receptor antagonist or alpha blocker with a Ki of 58.3 nM. Naftopidil (Flivas) is an antihypertensive agent. Naftopidil (Flivas) binds specifically to alpha 1-adrenoceptors. The Ki values are 58.3 nM for naftopidi. In Japan, naftopidil is being used as a treatment for the bladder outlet obstruction in patients with benign prostatic hyperplasia.

REFERENCES
[1]Himmel, Herbert M Naftopidil, a novel antihypertensive drug Cardiovascular Drug Reviews (1994), 12(1), 32-47.
[2] Yuan JinQiu; Liu Yali; Yang ZuYao; Qin Xiwen; Yang KeHu; Mao Chen; The efficacy and safety of alpha-1 blockers for benign prostatic hyperplasia: an overview of 15 systematic reviews Current medical research and opinion (2013), 29(3), 279-87.
[3] Sakai H, Igawa T, Onita T, Furukawa M, Hakariya T, Hayashi M, Matsuya F, Shida Y, Nishimura N, Yogi Y, Tsurusaki T, Takehara K, Nomata K, Shiraishi K, Shono T, Aoki D, Kanetake H, Efficacy of naftopidil in patients with overactive bladder associated with benign prostatic hyperplasia: prospective randomized controlled study to compare differences in efficacy between morning and evening medication. Hinyokika Kiyo. 2011 Jan;57(1):7-13.
[4] Masumori, Naoya Naftopidil for the treatment of urinary symptoms in patients with benign prostatic hyperplasia Therapeutics and Clinical Risk Management (2011), 7, 227-238.

GHS

Pictograms

Signal Word
Warning

Hazard Statements
H315; H319; H335

Precautionary Statements
P261; P264; P271; P280; P302+P352; P304+P340; P305+P351+P338; P312; P321; P332+P313; P337+P313; P362; P403+P233; P405; P501


RELATED PRODUCTS
F011Naftopidil dihydrochloride
O220Naftopidil

Current as of October 17, 2019


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For research use only. Not for diagnostic or therapeutic use.
Not for human use.


CATEGORIES

 APIs and Bioactives > Alpha Blockers


PubChem
  @PubMed