170729-80-3 Aprepitant AKSci L982
 
 
Loading Please Wait...
  L982    
Aprepitant
, 99% (HPLC)
 
Emend




IDENTITY
CAS Number:170729-80-3
MDL Number:MFCD08277635
MF:C23H21F7N4O3
MW:534.43
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:99% (HPLC)
Physical Form (at 20°C):Solid
Melting Point:251-255°C
Optical Rotation:+60.0° - +71.0° (c=0.68, MeOH)
Long-Term Storage:Store long-term at -20°C
DOT/IATA TRANSPORT INFORMATION
Not hazardous material

BIOLOGICAL INFO
Solubility:68mg/10ml of MeOH: clear colorless solution
Application(s):Substance P antagonists (SPA)

REVIEW

 A novel selective neurokinin-1 (NK-1) receptor antagonist. Aprepitant is a long-acting prodrug acetal single enantiomer antiemetic used for the prevention of nausea and vomiting associated with highly emetogenic cancer chemotherapy. In vitro studies using human liver microsomes show that it is metabolized primarily by CYP3A4 with minor metabolism by CYP2C19 and CYP1A2

REFERENCES
[1]Huffman, Mark; WO 2003089429 A1 2003.
[2] Elati, Chandrashekar R.; Tetrahedron Letters 2007, V48(45), P8001-8004.
[3] Braun, Doris E.; New Journal of Chemistry 2008, V32(10), P1677-1685.
[4] Anon.; IP.com Journal 2008, V8(12B), P35-36.

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Warning

Hazard Statements
H315; H319; H335

Precautionary Statements
P261; P264; P271; P280; P302+P352; P304+P340; P305+P351+P338; P312; P321; P332+P313; P337+P313; P362; P403+P233; P405; P501


RELATED PRODUCTS
L982Aprepitant
W48573-(Chloromethyl)-1H-1,2,4-triazol-5(4H)-one
W51434-Benzyl-2-hydroxymorpholin-3-one
X9712(R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethan-1-ol
Y0383(R)-4-benzyl-2-((R)-1-(3,5-bis(trifluoromethyl)phenyl)ethoxy)morpholin-3-one
Y0384(2R,3S)-2-((R)-1-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(4-fluorophenyl)morpholine hydrochloride
Y0385Methyl 2-(2-chloro-1-iminoethyl)hydrazinecarboxylate

Current as of April 15, 2024


Download SDS Request COA

All products are stocked and shipped from San Francisco Bay Area, California, USA.

⚠️
All products are for research and development use only, not for any other uses, and must be handled by technically-qualified persons.

These products are explicitly not intended to be used in foods and/or cosmetics and/or drugs (human and veterinary) and/or consumer products and/or biocides and/or pesticides of any kind unless explicitly stated otherwise.

Products are not sold to individuals. We do not ship to residential addresses. Consumer orders will be cancelled without notice.

New customers undergo an internal onboarding process. As part of this process, new customers may be asked for more information. Additional restrictions may apply.



CATEGORIES

 APIs and Bioactives >


PubChem