89365-50-4 Salmeterol AKSci K590
 
 
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  K590    
Salmeterol
, 98% (HPLC)
 
4-Hydroxy-a1-[[[6-(4-phenylbutoxy)hexyl]amino]methyl]-1,3-benzenedimethanol




IDENTITY
CAS Number:89365-50-4
MDL Number:MFCD00867037
MF:C25H37NO4
MW:415.57
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:98% (HPLC)
Physical Form (at 20°C):Solid
Melting Point:75-77°C
Density:1.1
Refractive Index:1.56
Long-Term Storage:Store long-term at -20°C
DOT/IATA TRANSPORT INFORMATION
Not hazardous material

BIOLOGICAL INFO
Solubility:Soluble to 50 mM in Ethanol and to 100 mM in
Application(s):Long-acting beta2-adrenergic receptor agonist

REVIEW

 Salmeterol's long, lipophilic side chain binds to exosites near beta(2)-receptors in the lungs and on bronchiolar smooth muscle, allowing the active portion of the molecule to remain at the receptor site, continually binding and releasing. Beta(2)-receptor stimulation in the lung causes relaxation of bronchial smooth muscle, bronchodilation, and increased bronchial airflow.

REFERENCES
[1]Salpeter SR, Buckley NS, Ormiston TM, Salpeter EE: Meta-analysis: effect of long-acting beta-agonists on severe asthma exacerbations and asthma-related deaths. Ann Intern Med. 2006 Jun 20;144(12):904-12. Epub 2006 Jun 5.

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Warning

Hazard Statements
H315; H319; H335

Precautionary Statements
P261; P264; P271; P280; P302+P352; P304+P340; P305+P351+P338; P312; P321; P332+P313; P337+P313; P362; P403+P233; P405; P501


RELATED PRODUCTS
K590Salmeterol
V1621Salmeterol xinafoate

Current as of September 29, 2022


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CATEGORIES

 APIs and Bioactives > Adrenergic Agonists


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