REVIEW Manidipine dihydrochloride is a racemic, lipophilic, third-generation dihydropyridine calcium channel blocker used as an antihypertensive. It has high selectivity for the vasculature, inducing marked peripheral vasodilation with negligible cardiodepression. In addition, manidipine does not significantly affect norepinephrine levels, suggesting a lack of sympathetic activation.
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