89226-75-5 Manidipine 2HCl AKSci K588
 
 
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  K588    
Manidipine 2HCl
, 98% (HPLC)
 
Manidipine dihydrochloride
Franidipine hydrochloride




IDENTITY
CAS Number:89226-75-5
MDL Number:MFCD00896434
MF:C35H40Cl2N4O6
MW:683.62
SPECIFICATIONS & PROPERTIES
Purity:98% (HPLC)
Spectra:LCMS, FT-IR, HPLC
Physical Form:Light yellow powder or crystals
Melting Point:228-235°C
Long-Term Storage:Store at room temperature
UN #:UN2811
Hazard Class:6.1
Packing Group:III

BIOLOGICAL INFO
Solubility:DMSO: 21mg/mL; H2O: <1mg/mL; EtOH: <1mg/mL
Application(s):Calcium channel blocker
Form:2HCl salt

REVIEW

 Manidipine dihydrochloride is a racemic, lipophilic, third-generation dihydropyridine calcium channel blocker used as an antihypertensive. It has high selectivity for the vasculature, inducing marked peripheral vasodilation with negligible cardiodepression. In addition, manidipine does not significantly affect norepinephrine levels, suggesting a lack of sympathetic activation.

REFERENCES
[1]Meguro, Kanji; Nagaoka, Akinobu Dihydropyridine derivatives and their use Eur. Pat. Appl. (1983), EP 94159 A1 19831116.
[2] Meguro, Kanji; Aizawa, Masahiro; Sohda, Takashi; Kawamatsu, Yutaka; Nagaoka, Akinobu New 1,4-dihydropyridine derivatives with potent and long-lasting hypotensive effect Chemical & Pharmaceutical Bulletin (1985), 33(9), 3787-97.
[3] Kakihana, Mitsuru; Suno, Masahiro; Nagaoka, Akinobu Antihypertensive effect of CV-4093, a new calcium antagonist, in three rat models of hypertension Japanese Journal of Pharmacology (1988), 48(2), 223-8.
[4] Ruggenenti P, Lauria G, Iliev IP, Fassi A, Ilieva AP, Rota S, Chiurchiu C, Barlovic DP, Sghirlanzoni A, Lombardi R, Penza P, Cavaletti G, Piatti ML, Frigeni B, Filipponi M, Rubis N, Noris G, Motterlini N, Ene-Iordache B, Gaspari F, Perna A, Zaletel J, Bossi A, Dodesini AR, Trevisan R, Remuzzi G; DEMAND Study Investigators (2011). Effects of manidipine and delapril in hypertensive patients with type 2 diabetes mellitus: the delapril and manidipine for nephroprotection in diabetes (DEMAND) randomized clinical trial. Hypertension. 58(5):776-83. PMID 21931073.

GHS

Pictograms

Signal Word
Warning

Hazard Statements
H301

Precautionary Statements
P261; P280; P305+P351+P338; P304+P340; P405; P501


RELATED PRODUCTS
K588Manidipine 2HCl
G753Manidipine

Current as of June 24, 2019


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CATEGORIES

 APIs and Bioactives > Calcium Channel Blockers


PubChem