89226-75-5, 89226-50-6 Manidipine 2HCl AKSci K588
 
 
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  K588    
Manidipine 2HCl, 98% (HPLC)
 
Manidipine dihydrochloride
Franidipine hydrochloride
IDENTITY
CAS Number:89226-75-5, 89226-50-6
MDL Number:MFCD00896434
MF:C35H40Cl2N4O6
MW:683.62
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:98% (HPLC)
Physical Form (at 20°C):Solid
Melting Point:228-235°C
Long-Term Storage:Store long-term in a cool, dry place
DOT/IATA TRANSPORT INFORMATION
UN #:UN2811
Hazard Class:6.1; Poison
Packing Group:III
A hazmat fee may apply depending on the amount ordered, as indicated in the list of package sizes.

BIOLOGICAL INFO
Solubility:DMSO: 21mg/mL; H2O: <1mg/mL; EtOH: <1mg/mL
Application(s):Calcium channel blocker
Form:2HCl salt

REVIEW
 Manidipine dihydrochloride is a racemic, lipophilic, third-generation dihydropyridine calcium channel blocker used as an antihypertensive. It has high selectivity for the vasculature, inducing marked peripheral vasodilation with negligible cardiodepression. In addition, manidipine does not significantly affect norepinephrine levels, suggesting a lack of sympathetic activation.

REFERENCES
[1]Meguro, Kanji; Nagaoka, Akinobu Dihydropyridine derivatives and their use Eur. Pat. Appl. (1983), EP 94159 A1 19831116.
[2] Meguro, Kanji; Aizawa, Masahiro; Sohda, Takashi; Kawamatsu, Yutaka; Nagaoka, Akinobu New 1,4-dihydropyridine derivatives with potent and long-lasting hypotensive effect Chemical & Pharmaceutical Bulletin (1985), 33(9), 3787-97.
[3] Kakihana, Mitsuru; Suno, Masahiro; Nagaoka, Akinobu Antihypertensive effect of CV-4093, a new calcium antagonist, in three rat models of hypertension Japanese Journal of Pharmacology (1988), 48(2), 223-8.
[4] Ruggenenti P, Lauria G, Iliev IP, Fassi A, Ilieva AP, Rota S, Chiurchiu C, Barlovic DP, Sghirlanzoni A, Lombardi R, Penza P, Cavaletti G, Piatti ML, Frigeni B, Filipponi M, Rubis N, Noris G, Motterlini N, Ene-Iordache B, Gaspari F, Perna A, Zaletel J, Bossi A, Dodesini AR, Trevisan R, Remuzzi G; DEMAND Study Investigators (2011). Effects of manidipine and delapril in hypertensive patients with type 2 diabetes mellitus: the delapril and manidipine for nephroprotection in diabetes (DEMAND) randomized clinical trial. Hypertension. 58(5):776-83. PMID 21931073.

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Warning

Hazard Statements
H301

Precautionary Statements
P261; P280; P305+P351+P338; P304+P340; P405; P501

RELATED PRODUCTS
K588Manidipine 2HCl
G753Manidipine

Current as of March 29, 2023


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CATEGORIES
 APIs and Bioactives > Calcium Channel Blockers


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