REVIEW Cefpirome sulfate (HR 810) is a fourth-generation cephalosporin. Trade names include Cefrom, Keiten, Broact, Cefir. Cefpirome is considered highly active against Gram-negative bacteria, including Pseudomonas aeruginosa, and Gram-positive bacteria. Cefpirome exhibits minimal concentration dependent killing and produces prolonged postantibiotic effects only with Staphylococcus aureus Cefpirome sulfate inhibits bacterial cell wall synthesis by binding to one or more of the penicillin-binding proteins (PBPs). This inhibits the final transpeptidation step of peptidoglycan synthesis in bacterial cell walls, thus inhibiting cell wall biosynthesis. Bacteria eventually lyse due to ongoing activity of cell wall autolytic enzymes (autolysins and murein hydrolases) while cell wall assembly is arrested. Currently, Bacteroides fragilis, Enterococci, Pseudomonas spp. and Staphylococci are resistant to cefpirome sulfate, and some Haemophilus spp. and Pneumococci have developed resistance to cefpirome sulfate to varying degrees.
REFERENCES
[1]
Lattrell, R.; Duerckheimer, W.; Klesel, N.; Kirrstetter, R.; Seibert, G.; Wieduwilt, M. HR 810, a new parenteral cephalosporin. I. Chemistry and physical properties Edited by Spitzy, K. H.; Karrer, K Proc. Int. Congr. Chemother., 13th (1983), 4, 99/1-99/4.
[2]
Kirrstetter, R.; Duerckheimer, W.; Lattrell, R.; Mencke, B.; Scheunemann, K.; Schwab, W.; Seeger, K.; Winkler, I. HR 810, a new parenteral cephalosporin. III. Synthesis and structure-activity relationships in the series of HR 810. Influence of syn-oxime substitution Edited by Spitzy, K. H.; Karrer, K Proc. Int. Congr. Chemother., 13th (1983), 4, 99/9-99/12.
[3]
Arai, Susumu; Kobayashi, Shinzo; Hayashi, Shoryo In vitro antibacterial activity of cefpirome sulfate against clinical isolates Chemotherapy (Tokyo) (1991), 39(Suppl. 1), 516-21.
[4]
Shiroishi, Hideyuki; Okui, Kiyoshi; Saito, Kenji; Hasegawa, Yoshinari In vitro antibacterial activity of a new cephalosporin, cefpirome Chemotherapy (Tokyo) (1991), 39(Suppl. 1), 522-6.
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