79307-93-0 Azelastine HCl AKSci K399
 
 
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  K399    AKSci Reference Standard
Azelastine HCl
, 99% (HPLC)
 
4-[(4-Chlorophenyl)methyl]-2-(1-methylazepan-4-yl)phthalazin-1-one hydrochloride
Allergodil
Rhinolast
more..




IDENTITY
CAS Number:79307-93-0
MDL Number:MFCD00242783
MF:C22H25Cl2N3O
MW:418.36
SPECIFICATIONS & PROPERTIES
Purity:99% (HPLC)
Spectra:LCMS, HPLC
Physical Form:White to off-white powder
Melting Point:225-229°C
Long-Term Storage:Store long-term at -20°C

BIOLOGICAL INFO
Application(s):Selective histamine antagonist
Form:HCl salt

REVIEW

 Azelastine competes with histamine for the H1-receptor sites on effector cells and acts as an antagonist by inhibiting the release of histamine and other mediators involved in the allergic response.

REFERENCES
[1]Lumry W, Prenner B, Corren J, Wheeler W (September 2007). Efficacy and safety of azelastine nasal spray at a dose of 1 spray per nostril twice daily. Annals of Allergy, Asthma & Immunology 99 (3): 267-72. doi:10.1016/S1081-1206(10)60663-1. PMID 17910331.
[2] Ciprandi G, Ricca V, Passalacqua G, et al. (March 1997). Seasonal rhinitis and azelastine: long- or short-term treatment?. The Journal of Allergy and Clinical Immunology 99 (3): 301-7. doi:10.1016/S0091-6749(97)70046-0. PMID 9058684.
[3] Horak, Friedrich; Zieglmayer, Ursula Petra (2009). Azelastine nasal spray for the treatment of allergic and nonallergic rhinitis. Expert Review of Clinical Immunology 5 (6): 659-69. doi:10.1586/eci.09.38. PMID 20477689.
[4] Greiff L, Andersson M, Svensson C, Persson CG (April 1997). Topical azelastine has a 12-hour duration of action as assessed by histamine challenge-induced exudation of alpha 2-macroglobulin into human nasal airways. Clinical and Experimental Allergy 27 (4): 438-44. doi:10.1111/j.1365-2222.1997.tb00730.x. PMID 9146938.

GHS

Pictograms

Signal Word
Warning

Hazard Statements
H302

Precautionary Statements
P264; P270; P301+P312; P330; P501


RELATED PRODUCTS
C809Azelastine
K399Azelastine HCl

Current as of July 17, 2019

AKSci Reference Standards are high-purity, low-impurity compounds suitable for use as standards.


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CATEGORIES

 APIs and Bioactives > Antihistamines


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