76497-13-7 Sultamicillin AKSci K315
 
 
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  K315    AKSci Bulk Reagent
Sultamicillin
, 96% (HPLC)
 



IDENTITY
CAS Number:76497-13-7
MDL Number:MFCD00864948
MF:C25H30N4O9S2
MW:594.66
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:96% (HPLC)
Physical Form (at 20°C):Solid
Melting Point:190°C
Long-Term Storage:Store long-term at 2-8°C
DOT/IATA TRANSPORT INFORMATION
Not hazardous material

BIOLOGICAL INFO
Application(s):Antibiotic

REVIEW

 Sultamicillin is an antibiotic combination (codrug or mutual prodrug). It contains esterified ampicillin and sulbactam and is marketed under a number of trade names, including Saltum from Morepen Lab and Unasyn from Pfizer. It is a prodrug ester, which upon hydrolysis releases the active ampicillin and the beta-lactamase inhibitor sulbactam. Sulbactam extends the antibacterial activity of the ampicillin to include some beta-lactamase-producing strains of bacteria that would otherwise be resistant. The ampicillin inhibits bacterial cell wall synthesis by binding to one or more of the penicillin-binding proteins (PBPs). This inhibits the final transpeptidation step of peptidoglycan synthesis in bacterial cell walls, thus inhibiting cell wall biosynthesis. Bacteria eventually lyse due to ongoing activity of cell wall autolytic enzymes (autolysins and murein hydrolases) while cell wall assembly is arrested.

REFERENCES
[1]1,1-Dioxopenicillanoyloxymethyl 6-(D-alpha-amino-alpha-phenylacetamido)penicillanate Neth. Appl. (1982), NL 8104938 A 19820517.
[2] Godtfredsen, Wagn O.; Von Daehne, Welf beta-Lactam compounds, their antibacterial compositions and their use U.S. (1982), US 4342772 A 19820803.
[3] Ishiko, Junichi; Munehasu, Shiro; Sugiyama, Miho; Suzuki, Makoto; Ohtsuki, Isao General pharmacological effects of sultamicillin tosylate Chemotherapy (Tokyo) (1985), 33(Suppl. 2), 122-7.
[4] Okamoto, Yuruko; Maehara, Keigo; Iida, Yube; Mase, Kanshi; Yonezu, Seibun; Yasunaga, Kojiro; Ueda, Yoshihiro; Okubo, Hiroshi Basic and clinical studies of sultamicillin Chemotherapy (Tokyo) (1985), 33(Suppl. 2), 304-23.

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Warning

Hazard Statements
H315; H319; H335

Precautionary Statements
P261; P264; P271; P280; P302+P352; P304+P340; P305+P351+P338; P312; P321; P332+P313; P337+P313; P362; P403+P233; P405; P501


RELATED PRODUCTS
G324Sultamicillin tosylate
K315Sultamicillin

Current as of August 19, 2022


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CATEGORIES

 APIs and Bioactives > Antibacterials, Penicillins


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