REVIEW Ranitidine is a histamine H2-receptor antagonist that inhibits stomach acid production. It is also used alongside fexofenadine and other antihistamines for the treatment of skin conditions such as hives. It has 10% the affinity that cimetidine has to CYP450 so it causes fewer side effects, but other H2 blockers famotidine and nizatidine have no CYP450 significant interactions.
REFERENCES
[1]
Ulu ST, Tuncel M (2012). A sensitive and rapid determination of ranitidine in human plasma by HPLC with fluorescence detection and its application for a pharmacokinetic study. J Chromatogr Sci. 50(4):301-6. PMID 22345389.
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Izzettin FV, Sancar M, Okuyan B, Apikoglu-Rabus S, Cevikbas U (2012). Comparison of the protective effects of various antiulcer agents alone or in combination on indomethacin-induced gastric ulcers in rats. Exp Toxicol Pathol. 64(4):339-43. PMID 21030227.
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