14976-57-9 Clemastine fumarate AKSci J99863
 
 
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  J99863    
Clemastine fumarate
, 95%
 



IDENTITY
CAS Number:14976-57-9
MDL Number:MFCD00137486
MF:C21H26ClNO.C4H4O4
MW:459.96
EINECS:239-055-2
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:95%
Physical Form (at 20°C):Solid
Melting Point:177-180°C
Optical Rotation:+13° - +18° (c=1,MeOH)
Long-Term Storage:Store long-term in a cool, dry place
DOT/IATA TRANSPORT INFORMATION
Not hazardous material

BIOLOGICAL INFO
Solubility:DMSO: 35mg/mL; H2O: <1mg/mL; EtOH: 3mg/mL
Application(s):Selective histamine H1 receptor antagonist
Form:Fumarate salt

REVIEW

 Clemastine is a selective histamine H1 antagonist and binds to the histamine H1 receptor. This blocks the action of endogenous histamine, which subsequently leads to temporary relief of the negative symptoms brought on by histamine.

REFERENCES
[1]Hayashi H, Okajima M, Yamada K: Atrial T (Ta) loop in dogs with or without atrial injury. Am Heart J. 1976 May;91(5):607-17.
[2] 'Schran HF, Petryk L, Chang CT, O''Connor R, Gelbert MB: The pharmacokinetics and bioavailability of clemastine and phenylpropanolamine in single-component and combination formulations. J Clin Pharmacol. 1996 Oct;36(10):911-22. '

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Warning

Hazard Statements
H315; H319; H335

Precautionary Statements
P261; P264; P271; P280; P302+P352; P304+P340; P305+P351+P338; P312; P321; P332+P313; P337+P313; P362; P403+P233; P405; P501


RELATED PRODUCTS
E098Clemastine fumarate
M192Clemastine

Current as of April 19, 2024


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⚠️
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CATEGORIES

 APIs and Bioactives > Antihistamines


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