14976-57-9 Clemastine fumarate AKSci E098
 
 
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  E098    
Clemastine fumarate
, 98% (HPLC)
 



IDENTITY
CAS Number:14976-57-9
MDL Number:MFCD00137486
MF:C21H26ClNO.C4H4O4
MW:459.96
EINECS:239-055-2
SPECIFICATIONS & PROPERTIES
Purity:98% (HPLC)
Physical Form:White to off-white powder
Melting Point:177-180°C
Optical Rotation:+13° - +18° (c=1,MeOH)
Long-Term Storage:Store at room temperature

BIOLOGICAL INFO
Solubility:DMSO: 35mg/mL; H2O: <1mg/mL; EtOH: 3mg/mL
Application(s):Selective histamine H1 receptor antagonist
Form:Fumarate salt

REVIEW

 Clemastine is a selective histamine H1 antagonist and binds to the histamine H1 receptor. This blocks the action of endogenous histamine, which subsequently leads to temporary relief of the negative symptoms brought on by histamine.

REFERENCES
[1]Hayashi H, Okajima M, Yamada K: Atrial T (Ta) loop in dogs with or without atrial injury. Am Heart J. 1976 May;91(5):607-17.
[2] 'Schran HF, Petryk L, Chang CT, O''Connor R, Gelbert MB: The pharmacokinetics and bioavailability of clemastine and phenylpropanolamine in single-component and combination formulations. J Clin Pharmacol. 1996 Oct;36(10):911-22. '

GHS

Pictograms

Signal Word
Warning

Hazard Statements
H315; H319; H335

Precautionary Statements
P261; P264; P271; P280; P302+P352; P304+P340; P305+P351+P338; P312; P321; P332+P313; P337+P313; P362; P403+P233; P405; P501


RELATED PRODUCTS
E098Clemastine fumarate
M192Clemastine

Current as of October 22, 2019


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For research use only. Not for diagnostic or therapeutic use.
Not for human use.


CATEGORIES

 APIs and Bioactives > Antihistamines


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