155148-31-5 Plerixafor octahydrochloride AKSci J97029
 
 
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  J97029    
Plerixafor octahydrochloride
, 95%
 
JM 3100, AMD3100 octahydrochloride

Structure N/A

IDENTITY
CAS Number:155148-31-5
MDL Number:MFCD04974488
MF:C28H54N8.8HCl
MW:794.47
SPECIFICATIONS & PROPERTIES
Purity:95%
Physical Form:White powder
Melting Point:237-245°C
Long-Term Storage:Store long-term at -20°C

BIOLOGICAL INFO
Solubility:DMSO <1 mg/ml; Water 100 mg/ml; Ethanol <1 mg/ml
Application(s):A specific CXCR4 antagonist

REVIEW

 Plerixafor octahydrochloride is a selective bicyclam derivative which functions as a stem cell mobiliser via blocking the CXCR4 chemokine receptor. Studies suggest that it causes the rapid movement of stem cells out of bone marrow via blocking the CXCR4 receptor. Since the CXCR4 receptor is responsible for regulating metastasis in chemoresistant melanoma cells, blocking this receptor can possibly reduce the metastasis of melanoma cells. In addition, studies indicate that plerixafor octahydrochloride can inhibit the replication of human immunodeficiency virus in vitro by blocking the entry of the virus into cells. Furthermore, plerixafor octahydrochloride can also reduce the number of human CD4+ T cells.

REFERENCES
[1]Datema, R., et al., 1996. Antiviral efficacy in vivo of the anti-human immunodeficiency virus bicyclam SDZ SID 791 (JM 3100), an inhibitor of infectious cell entry. Antimicrobial agents and chemotherapy. 40(3): 750-4. PMID: 8851605
[2] Kim, Minah., et al., 2010. CXCR4 signaling regulates metastasis of chemoresistant melanoma cells by a lymphatic metastatic niche. Cancer research. 70(24): 10411-21. PMID: 21056990

GHS

Pictograms

Signal Word
Warning

Hazard Statements
H315; H319; H335

Precautionary Statements
P261; P264; P271; P280; P302+P352; P304+P340; P305+P351+P338; P312; P321; P332+P313; P337+P313; P362; P403+P233; P405; P501


RELATED PRODUCTS
B617Plerixafor
Y0232Plerixafor octahydrochloride

Current as of October 17, 2019


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For research use only. Not for diagnostic or therapeutic use.
Not for human use.


CATEGORIES

 APIs and Bioactives > Immunomodulators


PubChem