16595-80-5 Levamisole HCl AKSci J93921
 
 
Loading Please Wait...
  J93921    AKSci Bulk Reagent
Levamisole HCl
, 95%
 
(-)-2,3,5,6-Tetrahydro-6-phenylimidazo[2,1-b]thiazole hydrochloride
(-)-Tetramisole hydrochloride
(S)-(-)-6-Phenyl-2,3,5,6-tetrahydroimidazo[2,1-b]thiazole hydrochloride
more..




IDENTITY
CAS Number:16595-80-5
MDL Number:MFCD00012675
MF:C11H12N2S.HCl
MW:240.75
EINECS:240-654-6
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:95%
Physical Form (at 20°C):Solid
Melting Point:225-234°C
Optical Rotation:-130 - -122° (c=1, H2O)
Long-Term Storage:Store long-term in a cool, dry place
DOT/IATA TRANSPORT INFORMATION
UN #:UN2811
Hazard Class:6.1; Poison
Packing Group:III
A hazmat fee may apply to certain package sizes and shipment methods. Please check pricing table for an indicator of applicable hazmat fees.

BIOLOGICAL INFO
Solubility:DMSO: <1mg/mL; H2O: 48mg/mL; EtOH: <1mg/mL
Application(s):Alkaline phosphatase inhibitor
Form:HCl salt

REVIEW

 An anthelminthic and immunomodulator belonging to a class of synthetic imidazothiazole derivatives. Levamisole reversibly and noncompetitively inhibits most isoforms of alkaline phosphatase (e.g. human liver, bone, kidney, and spleen) except the intestinal and placental isoform.[19] It is thus used as an inhibitor along with substrate to reduce background alkaline phosphatase activity in biomedical assays involving detection signal amplification by intestinal alkaline phosphatase, for example in in situ hybridization or Western blot protocols.

REFERENCES
[1]Chang L, Duy do L, Mébarek S, Popowycz F, Pellet-Rostaing S, Lemaire M, Buchet R (2011). Synthesis and evaluation of thiophenyl derivatives as inhibitors of alkaline phosphatase. Bioorg Med Chem Lett. 21(8):2297-301. PMID 21421310.

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Danger

Hazard Statements
H301

Precautionary Statements
P264; P270; P301+P310; P321; P330; P405; P501


RELATED PRODUCTS
U487Levamisole
I013Levamisole HCl
R771Levamisole phosphate

Current as of October 15, 2024


Download SDS Request COA

All products are stocked and shipped from the SF Bay, California, USA via FedEx, UPS or DHL.
All batches backed with full quality assurance.
⚠️
All products are for research and development use only, not for any other uses, and must be handled by technically-qualified persons.

These products are explicitly not intended to be used in foods and/or cosmetics and/or drugs (human and veterinary) and/or consumer products and/or biocides and/or pesticides of any kind unless explicitly stated otherwise.

Products are not sold to individuals. We do not ship to residential addresses. Consumer orders will be cancelled without notice.

New customers undergo an internal onboarding process. As part of this process, new customers may be asked for more information. Additional restrictions may apply.



CATEGORIES

 APIs and Bioactives > Antiparasitics


PubChem