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BIOLOGICAL INFO
Solubility:
DMSO: <1mg/mL; H2O: 48mg/mL; EtOH: <1mg/mL
Application(s):
Alkaline phosphatase inhibitor
Form:
HCl salt
REVIEW An anthelminthic and immunomodulator belonging to a class of synthetic imidazothiazole derivatives. Levamisole reversibly and noncompetitively inhibits most isoforms of alkaline phosphatase (e.g. human liver, bone, kidney, and spleen) except the intestinal and placental isoform.[19] It is thus used as an inhibitor along with substrate to reduce background alkaline phosphatase activity in biomedical assays involving detection signal amplification by intestinal alkaline phosphatase, for example in in situ hybridization or Western blot protocols.
REFERENCES
[1]
Chang L, Duy do L, Mébarek S, Popowycz F, Pellet-Rostaing S, Lemaire M, Buchet R (2011). Synthesis and evaluation of thiophenyl derivatives as inhibitors of alkaline phosphatase. Bioorg Med Chem Lett. 21(8):2297-301. PMID 21421310.
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