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BIOLOGICAL INFO
Solubility:
CHCl3; H2O: insoluble
Application(s):
Strong binding affinities to dopamine and histamine receptors
Form:
Free Base
REVIEW Chlorprothixene blocks postsynaptic mesolimbic dopaminergic D1 and D2 receptors in the brain; depresses the release of hypothalamic and hypophyseal hormones and is believed to depress the reticular activating system thus affecting basal metabolism, body temperature, wakefulness, vasomotor tone, and emesis.
REFERENCES
[1]
Healy, David (1997). The antidepressant era. Cambridge: Harvard University Press. p. 182. ISBN 0-674-03958-0.
[2]
Sneader, Walter (2005). Drug discovery: a history. New York: Wiley. p. 410. ISBN 0-471-89980-1.
[3]
Kornhuber J, Muehlbacher M, Trapp S, Pechmann S, Friedl A, Reichel M, Mühle C, Terfloth L, Groemer T, Spitzer G, Liedl K, Gulbins E, Tripal P (2011). Identification of novel functional inhibitors of acid sphingomyelinase. PLoS ONE 6 (8): e23852. doi:10.1371/journal.pone.0023852.
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