113-59-7 Chlorprothixene AKSci G716
 
 
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  G716    AKSci Reference Standard
Chlorprothixene
, 99% (HPLC)
 
2-Chloro-9-(3-dimethylaminopropylidene)thioxanthene




IDENTITY
CAS Number:113-59-7
MDL Number:MFCD00869180
MF:C18H18ClNS
MW:315.86
EINECS:204-032-8
SPECIFICATIONS & PROPERTIES
Purity:99% (HPLC)
Spectra:LCMS, HPLC
Physical Form:Light yellow to yellow-brown powder
Melting Point:98-102°C
Long-Term Storage:Store long-term at 2-8°C
UN #:UN2811
Hazard Class:6.1; Poison
Packing Group:III

BIOLOGICAL INFO
Solubility:CHCl3; H2O: insoluble
Application(s):Strong binding affinities to dopamine and histamine receptors
Form:Free Base

REVIEW

 Chlorprothixene blocks postsynaptic mesolimbic dopaminergic D1 and D2 receptors in the brain; depresses the release of hypothalamic and hypophyseal hormones and is believed to depress the reticular activating system thus affecting basal metabolism, body temperature, wakefulness, vasomotor tone, and emesis.

REFERENCES
[1]Healy, David (1997). The antidepressant era. Cambridge: Harvard University Press. p. 182. ISBN 0-674-03958-0.
[2] Sneader, Walter (2005). Drug discovery: a history. New York: Wiley. p. 410. ISBN 0-471-89980-1.
[3] Kornhuber J, Muehlbacher M, Trapp S, Pechmann S, Friedl A, Reichel M, Mühle C, Terfloth L, Groemer T, Spitzer G, Liedl K, Gulbins E, Tripal P (2011). Identification of novel functional inhibitors of acid sphingomyelinase. PLoS ONE 6 (8): e23852. doi:10.1371/journal.pone.0023852.

GHS

Pictograms

Signal Word
Warning

Hazard Statements
H315; H319; H335

Precautionary Statements
P261; P264; P271; P280; P302+P352; P304+P340; P305+P351+P338; P312; P321; P332+P313; P337+P313; P362; P403+P233; P405; P501


RELATED PRODUCTS
G716Chlorprothixene
O289Chlorprothixene HCl

Current as of July 6, 2020

AKSci Reference Standards are high-purity, low-impurity compounds suitable for use as standards.


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CATEGORIES

 APIs and Bioactives > Dopamine Antagonists, Antipsychotics


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