191217-81-9 Pramipexole dihydrochloride monohydrate AKSci J60927
 
 
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  J60927    
Pramipexole dihydrochloride monohydrate, 95%
 
(S)-N6-Propyl-4,5,6,7-tetrahydrobenzo[d]thiazole-2,6-diamine dihydrochloride hydrate
IDENTITY
CAS Number:191217-81-9
MDL Number:MFCD02183927
MF:C10H17N3S.2HCl.H2O
MW:302.26
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:95%
Physical Form (at 20°C):Solid
Melting Point:296-305°C
Boiling Point:497°C
Optical Rotation:-64.0° - -69.0° (c=1, MeOH)
Long-Term Storage:Store long-term at 2-8°C
DOT/IATA TRANSPORT INFORMATION
Not hazardous material

BIOLOGICAL INFO
Solubility:DMSO: 41mg/mL; H2O: 61mg/mL; EtOH: <1mg/mL
Application(s):Partial/full D2S, D2L, D3, D4, receptor agonist
Form:2HCl salt

REVIEW
 Pramipexole is a dopamine agonist active at D3 and D2 receptor subtypes. Pramipexole has been found to have neuroprotective effects independent of its dopamine receptor agonism. It reduces mitochondrial reactive oxygen species (ROS) production and inhibits the activation of apoptotic pathways.

REFERENCES
[1]Mierau J, Schneider FJ, Ensinger HA, Chio CL, Lajiness ME, Huff RM: Pramipexole binding and activation of cloned and expressed dopamine D2, D3 and D4 receptors. Eur J Pharmacol. 1995 Jun 23;290(1):29-36.

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Warning

Hazard Statements
H302

Precautionary Statements
P261; P271; P270; P264; P301+P312+P330; P330; P304+P340; P312; P403; P233; P405; P501;


RELATED PRODUCTS
V0817Pramipexole dihydrochloride
G649Pramipexole dihydrochloride monohydrate

Current as of December 3, 2023


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CATEGORIES
 APIs and Bioactives > Dopamine Agonists


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