191217-81-9 Pramipexole dihydrochloride monohydrate AKSci G649
 
 
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  G649    
Pramipexole dihydrochloride monohydrate
, 98% (HPLC)
 
(S)-N6-Propyl-4,5,6,7-tetrahydrobenzo[d]thiazole-2,6-diamine dihydrochloride hydrate




IDENTITY
CAS Number:191217-81-9
MDL Number:MFCD02183927
MF:C10H17N3S.2HCl.H2O
MW:302.26
SPECIFICATIONS & PROPERTIES
Purity:98% (HPLC)
Spectra:LCMS, FT-IR, HPLC
Physical Form:White to off-white crystalline powder or powder
Melting Point:296-305°C
Boiling Point:497°C
Optical Rotation:-64.0° - -69.0° (c=1, MeOH)
Long-Term Storage:Store long-term at 2-8°C
UN #:Not hazmat

BIOLOGICAL INFO
Solubility:DMSO: 41mg/mL; H2O: 61mg/mL; EtOH: <1mg/mL
Application(s):Partial/full D2S, D2L, D3, D4, receptor agonist
Form:2HCl salt

REVIEW

 Pramipexole is a dopamine agonist active at D3 and D2 receptor subtypes. Pramipexole has been found to have neuroprotective effects independent of its dopamine receptor agonism. It reduces mitochondrial reactive oxygen species (ROS) production and inhibits the activation of apoptotic pathways.

REFERENCES
[1]Mierau J, Schneider FJ, Ensinger HA, Chio CL, Lajiness ME, Huff RM: Pramipexole binding and activation of cloned and expressed dopamine D2, D3 and D4 receptors. Eur J Pharmacol. 1995 Jun 23;290(1):29-36.

GHS

Pictograms

Signal Word
Warning

Hazard Statements
H315; H319; H335

Precautionary Statements
P261; P264; P271; P280; P302+P352; P304+P340; P305+P351+P338; P312; P321; P332+P313; P337+P313; P362; P403+P233; P405; P501


RELATED PRODUCTS
V0817Pramipexole dihydrochloride
G649Pramipexole dihydrochloride monohydrate

Current as of January 19, 2019


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CATEGORIES

 APIs and Bioactives > Dopamine Agonists


PubChem