229975-97-7 Atazanavir sulfate AKSci J55389
 
 
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  J55389    
Atazanavir sulfate, 95%
 
BMS-232632-05
Reyataz
IDENTITY
CAS Number:229975-97-7
MDL Number:MFCD08067748
MF:C38H52N6O7.H2SO4
MW:802.36
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:95%
Physical Form (at 20°C):White to light yellow powder or crystals
Melting Point:195-209°C
Optical Rotation:-46.1° (c=1, 1:1 MeOH/H2O, pH 2.6)
Long-Term Storage:Store long-term at -20°C
DOT/IATA TRANSPORT INFORMATION
Not hazardous material

BIOLOGICAL INFO
Solubility:DMSO: 104mg/mL; H2O: <1mg/mL; EtOH: 20mg/mL
Application(s):HIV protease inhibitor; Azapeptide inhibitor of HIV-1 protease
Form:Sulfate salt

REVIEW
 Atazanavir selectively inhibits the virus-specific processing of viral Gag and Gag-Pol polyproteins in HIV-1 infected cells by binding to the active site of HIV-1 protease, thus preventing the formation of mature virions. Atazanavir is not active against HIV-2.

REFERENCES
[1]Singh, Janak; Pudipeddi, Madhusudhan; Lindrud, Mark D. Bisulfate salt of HIV protease inhibitor.
[2] Xu, Zhongmin; Singh, Janak; Schwinden, Mark D.; Zheng, Bin; Kissick, Thomas P.; Patel, Bharat; Humora, Michael J.; Quiroz, Fernando; Dong, Lin; Hsieh, Dau-Ming; et al Process Research and Development for an Efficient Synthesis of the HIV Protease Inhibitor BMS-232632 Organic Process Research & Development (2002), 6(3), 323-328.
[3] Kim, Soojin; Lotz, Bruce T.; Malley, Mary F.; Gougoutas, Jack Z.; Davidovich, Martha; Srivastava, Sushil Synthesis of atazanavir bisulfate and preparation and analysis of novel crystalline forms for administration for treatment of HIV PCT Int. Appl. (2005), WO 2005108349 A2 20051117.
[4] Piliero PJ.Atazanavir: a novel HIV-1 protease inhibitor. Expert Opin Investig Drugs. 2002 Sep;11(9):1295-301.

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Warning

Hazard Statements
H315; H319; H335

Precautionary Statements
P261; P264; P271; P280; P302+P352; P304+P340; P305+P351+P338; P312; P321; P332+P313; P337+P313; P362; P403+P233; P405; P501

RELATED PRODUCTS
N349Atazanavir sulfate
R133Atazanavir

Current as of January 27, 2022


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CATEGORIES
 APIs and Bioactives > Antivirals, HIV Protease Inhibitors


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