HIV protease inhibitor; Azapeptide inhibitor of HIV-1 protease
Form:
Sulfate salt
REVIEW Atazanavir selectively inhibits the virus-specific processing of viral Gag and Gag-Pol polyproteins in HIV-1 infected cells by binding to the active site of HIV-1 protease, thus preventing the formation of mature virions. Atazanavir is not active against HIV-2.
REFERENCES
[1]
Singh, Janak; Pudipeddi, Madhusudhan; Lindrud, Mark D. Bisulfate salt of HIV protease inhibitor.
[2]
Xu, Zhongmin; Singh, Janak; Schwinden, Mark D.; Zheng, Bin; Kissick, Thomas P.; Patel, Bharat; Humora, Michael J.; Quiroz, Fernando; Dong, Lin; Hsieh, Dau-Ming; et al Process Research and Development for an Efficient Synthesis of the HIV Protease Inhibitor BMS-232632 Organic Process Research & Development (2002), 6(3), 323-328.
[3]
Kim, Soojin; Lotz, Bruce T.; Malley, Mary F.; Gougoutas, Jack Z.; Davidovich, Martha; Srivastava, Sushil Synthesis of atazanavir bisulfate and preparation and analysis of novel crystalline forms for administration for treatment of HIV PCT Int. Appl. (2005), WO 2005108349 A2 20051117.
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