152520-56-4 Nebivolol HCl AKSci J53621
 
 
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  J53621    
Nebivolol HCl
, 95%
 
Narbivolol
Nebilet
Bystolic
more..




IDENTITY
CAS Number:152520-56-4
MDL Number:MFCD07357273
MF:C22H26ClF2NO4
MW:441.90
SPECIFICATIONS & PROPERTIES
Purity:95%
Physical Form:White to off-white crystalline powder
Melting Point:219-222°C
Long-Term Storage:Store at room temperature

BIOLOGICAL INFO
Solubility:DMSO: =20 mg/mL
Application(s):beta-1-adrenoceptor inhibitor
Form:HCl salt

REVIEW

 Nebivolol is a chiral, selective, third-generation beta1-receptor antagonist used in the treatment of hypertension and chronic heart failure. It blocks activation of adrenergic receptors by epinephrine, reversing its effects and lowering heart rate and blood pressure. It has additional nitric oxide-mediated vasodilating and antioxidant properties, along with a favorable metabolic profile.

REFERENCES
[1]Noe, Christian R.; Jasic, Muhamed; Kollmann, Hermann; Lachmann, Bodo Process for preparation of Nebivolol using 6-fluoro-3,4-dihydrobenzopyran-2-carboxaldehyde cyanohydrins. PCT Int. Appl. (2007), WO 2007009143 A2 20070125.
[2] Khamar, Bakulesh Mafatlal; Thakor, Indrajit; Patel, Mahesh; Jadav, Kalpesh; Parikh, Ankur; Joshi, Atul Chhotalal; Ponnaiah, Ravi; Modi, Indravadan Ambalal An improved process for the preparation of nebivolol hydrochloride Eur. Pat. Appl. (2010), EP 2163551 A1 20100317.
[3] Maragni, Paolo; Michieletto, Ivan; Volpicelli, Raffaella; Soriato, Giorgio; Foletto, Johnny; Cotarca, Livius; Verzini, Massimo Process for preparing nebivolol PCT Int. Appl. (2010), WO 2010049455 A1 20100506.
[4] Gielen W, Cleophas TJ, Agrawal R: Nebivolol: a review of its clinical and pharmacological characteristics. Int J Clin Pharmacol Ther. 2006 Aug;44(8):344-57.

GHS

Pictograms

Signal Word
Warning

Hazard Statements
H315; H319; H335

Precautionary Statements
P261; P264; P271; P280; P302+P352; P304+P340; P305+P351+P338; P312; P321; P332+P313; P337+P313; P362; P403+P233; P405; P501


RELATED PRODUCTS
M753Nebivolol
E119Nebivolol HCl

Current as of July 11, 2020


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CATEGORIES

 APIs and Bioactives > Beta Blockers


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