224785-91-5 Vardenafil hydrochloride AKSci J20630
 
 
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  J20630    
Vardenafil hydrochloride
, 98%
 
Staxyn




IDENTITY
CAS Number:224785-91-5
MDL Number:MFCD07369690
MF:C23H32N6O4S.HCl
MW:525.64
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:98%
Physical Form (at 20°C):Solid
Melting Point:227-230°C
Long-Term Storage:Store long-term in a cool, dry place
DOT/IATA TRANSPORT INFORMATION
UN #:UN2811
Hazard Class:6.1; Poison
Packing Group:III
A hazmat fee may apply, depending on the amount ordered.

BIOLOGICAL INFO
Application(s):PDE5 inhibitor
Form:HCl salt

REVIEW

 Vardenafil inhibits the cGMP specific phosphodiesterase type 5 (PDE5) which is responsible for degradation of cGMP in the corpus cavernosum located around the penis. Penile erection during sexual stimulation is caused by increased penile blood flow resulting from the relaxation of penile arteries and corpus cavernosal smooth muscle. This response is mediated by the release of nitric oxide (NO) from nerve terminals and endothelial cells, which stimulates the synthesis of cGMP in smooth muscle cells. Cyclic GMP causes smooth muscle relaxation and increased blood flow into the corpus cavernosum. The inhibition of phosphodiesterase type 5 (PDE5) by vardenafil enhances erectile function by increasing the amount of cGMP.

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Danger

Hazard Statements
H301; H311; H315; H319; H332; H335

Precautionary Statements
P264; P270; P301+P310+P330; P405; P501


RELATED PRODUCTS
E429Vardenafil
F755Vardenafil hydrochloride

Current as of October 1, 2022


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⚠️
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CATEGORIES

 APIs and Bioactives > PDE5 Inhibitors


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