224785-91-5 Vardenafil hydrochloride AKSci F755
 
 
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  F755    AKSci Reference Standard
Vardenafil hydrochloride
, 99% (HPLC), powder
 
Staxyn




IDENTITY
CAS Number:224785-91-5
MDL Number:MFCD07369690
MF:C23H32N6O4S.HCl
MW:525.64
SPECIFICATIONS & PROPERTIES
Purity:99% (HPLC), powder
Spectra:LCMS, HPLC
Physical Form:White to off-white powder and chunks
Melting Point:227-230°C
Long-Term Storage:Store at room temperature
UN #:UN2811
Hazard Class:6.1
Packing Group:III

BIOLOGICAL INFO
Application(s):PDE5 inhibitor
Form:HCl salt

REVIEW

 Vardenafil inhibits the cGMP specific phosphodiesterase type 5 (PDE5) which is responsible for degradation of cGMP in the corpus cavernosum located around the penis. Penile erection during sexual stimulation is caused by increased penile blood flow resulting from the relaxation of penile arteries and corpus cavernosal smooth muscle. This response is mediated by the release of nitric oxide (NO) from nerve terminals and endothelial cells, which stimulates the synthesis of cGMP in smooth muscle cells. Cyclic GMP causes smooth muscle relaxation and increased blood flow into the corpus cavernosum. The inhibition of phosphodiesterase type 5 (PDE5) by vardenafil enhances erectile function by increasing the amount of cGMP.

GHS

Pictograms

Signal Word
Danger

Hazard Statements
H301; H311; H315; H319; H332; H335

Precautionary Statements
P264; P270; P301+P310+P330; P405; P501


RELATED PRODUCTS
E429Vardenafil
F755Vardenafil hydrochloride

Current as of October 20, 2019

AKSci Reference Standards are high-purity, low-impurity compounds suitable for use as standards.


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For research use only. Not for diagnostic or therapeutic use.
Not for human use.


CATEGORIES

 APIs and Bioactives > PDE5 Inhibitors


PubChem