14976-57-9 Clemastine fumarate AKSci J11480
 
 
Loading Please Wait...
  J11480    AKSci Reference Standard
Clemastine fumarate
, >99% (HPLC), powder
 



IDENTITY
CAS Number:14976-57-9
MDL Number:MFCD00137486
MF:C21H26ClNO.C4H4O4
MW:459.96
EINECS:239-055-2
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:>99% (HPLC), powder
Physical Form (at 20°C):Solid
Melting Point:177-180°C
Optical Rotation:+13° - +18° (c=1,MeOH)
Long-Term Storage:Store long-term in a cool, dry place
DOT/IATA TRANSPORT INFORMATION
Not hazardous material

BIOLOGICAL INFO
Solubility:DMSO: 35mg/mL; H2O: <1mg/mL; EtOH: 3mg/mL
Application(s):Selective histamine H1 receptor antagonist
Form:Fumarate salt

REVIEW

 Clemastine is a selective histamine H1 antagonist and binds to the histamine H1 receptor. This blocks the action of endogenous histamine, which subsequently leads to temporary relief of the negative symptoms brought on by histamine.

REFERENCES
[1]Hayashi H, Okajima M, Yamada K: Atrial T (Ta) loop in dogs with or without atrial injury. Am Heart J. 1976 May;91(5):607-17.
[2] 'Schran HF, Petryk L, Chang CT, O''Connor R, Gelbert MB: The pharmacokinetics and bioavailability of clemastine and phenylpropanolamine in single-component and combination formulations. J Clin Pharmacol. 1996 Oct;36(10):911-22. '

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Warning

Hazard Statements
H315; H319; H335

Precautionary Statements
P261; P264; P271; P280; P302+P352; P304+P340; P305+P351+P338; P312; P321; P332+P313; P337+P313; P362; P403+P233; P405; P501


RELATED PRODUCTS
E098Clemastine fumarate
M192Clemastine

Current as of December 3, 2022

AKSci Reference Standards are high-purity, low-impurity compounds suitable for use as standards.


Download SDS Request COA

⚠️
These chemical products are for research and development use only. They are not for diagnostic, therapeutic, cosmetic, or human and animal uses. They are not sold to individuals. Additional restrictions may apply.

New customers undergo an internal onboarding process. As part of this process, new customers may be asked for more information.


CATEGORIES

 APIs and Bioactives > Antihistamines


PubChem