64211-46-7 Oxiconazole nitrate AKSci I628
 
 
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  I628    AKSci Reference Standard
Oxiconazole nitrate
, 98% (HPLC)
 
Myfungar
Oceral
Oxistat
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IDENTITY
CAS Number:64211-46-7
MDL Number:MFCD01727545
MF:C18H13Cl4N3O.HNO3
MW:492.14
EINECS:264-730-3
SPECIFICATIONS & PROPERTIES
Purity:98% (HPLC)
Physical Form:White to off-white crystalline powder
Melting Point:137-142°C
Long-Term Storage:Store at room temperature

BIOLOGICAL INFO
Application(s):Antifungal agent

REVIEW

 Oxiconazole inhibits ergosterol biosynthesis, which is required for cytoplasmic membrane integrity of fungi. It acts to destabilize the fungal cyctochrome P450 51 enzyme (also known as Lanosterol 14-alpha demethylase). This is vital in the cell membrance structure of the fungus. Its inhibition leads to cell lysis. Oxiconazole has also been shown in inhibit DNA synthesis and suppress intracellular concentrations of ATP. Like other imidazole antifungals, Oxiconazole can increase membrane permeability to zinc, augmenting its cytotoxicity.

REFERENCES
[1]Matsui H, Sakanashi Y, Oyama TM, Oyama Y, Yokota S, Ishida S, Okano Y, Oyama TB, Nishimura Y: Imidazole antifungals, but not triazole antifungals, increase membrane Zn2+ permeability in rat thymocytes Possible contribution to their cytotoxicity. Toxicology. 2008 Jun 27;248(2-3):142-50. Epub 2008 Apr 7.
[2] Fromtling RA: Overview of medically important antifungal azole derivatives. Clin Microbiol Rev. 1988 Apr;1(2):187-217.

GHS

Pictograms

Signal Word
Warning

Hazard Statements
H315; H319; H335

Precautionary Statements
P261; P264; P271; P280; P302+P352; P304+P340; P305+P351+P338; P312; P321; P332+P313; P337+P313; P362; P403+P233; P405; P501


RELATED PRODUCTS
F007Oxiconazole
I628Oxiconazole nitrate

Current as of October 20, 2019

AKSci Reference Standards are high-purity, low-impurity compounds suitable for use as standards.


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For research use only. Not for diagnostic or therapeutic use.
Not for human use.


CATEGORIES

 APIs and Bioactives > Fungicides


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