81129-83-1 Cilastatin sodium AKSci I422
 
 
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  I422    
Cilastatin sodium
, 98% (HPLC)
 
Cilastatin sodium salt




IDENTITY
CAS Number:81129-83-1
MDL Number:MFCD08459332
MF:C16H25N2NaO5S
MW:380.43
EINECS:279-694-4
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:98% (HPLC)
Spectra:LCMS, HPLC
Physical Form:White to off-white to light yellow powder
Melting Point:158-161°C
Long-Term Storage:Store long-term at 2-8°C
HAZARDOUS MATERIALS INFORMATION
Not hazardous material

BIOLOGICAL INFO
Solubility:water: 10 mg/mL, clear, colorless to faintly yellow
Application(s):Dehydropeptidase-I and leukotriene D4 dipeptidase inhibitor.

REVIEW

 Cilastatin is a specific and reversible renal dehydropeptidase-I inhibitor. Since the antibiotic, imipenem, is hydrolyzed by dehydropeptidase-I, which resides in the brush border of the renal tubule, cilastatin is administered with imipenem to block the metabolism and thus the inactivation of imipenem so that antibacterial levels of imipenem can be attained in the urine. The drug also prevents the metabolism of leukotriene D4 to leukotriene E4 through the inhibition of leukotriene D4 dipeptidase.

REFERENCES
[1]Keynan S, Hooper NM, Felici A, Amicosante G, Turner AJ: The renal membrane dipeptidase (dehydropeptidase I) inhibitor, cilastatin, inhibits the bacterial metallo-beta-lactamase enzyme CphA. Antimicrob Agents Chemother. 1995 Jul;39(7):1629-31.

GHS

Pictograms

Signal Word
Warning

Hazard Statements
H315; H319; H335

Precautionary Statements
P261; P264; P271; P280; P302+P352; P304+P340; P305+P351+P338; P312; P321; P332+P313; P337+P313; P362; P403+P233; P405; P501


RELATED PRODUCTS
I422Cilastatin sodium
K461Cilastatin

Current as of December 5, 2020


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CATEGORIES

 APIs and Bioactives > Antibacterials


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