132866-11-6 Lercanidipine HCl AKSci H990

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H990 AKSci Reference Standard
Lercanidipine HCl, 98% (HPLC)

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1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid 2-[(3,3-diphenylpropyl)

IDENTITY
CAS Number:	132866-11-6
MDL Number:	MFCD07773089
MF:	C36H42ClN3O6
MW:	648.19

SPECIFICATIONS & PROPERTIES
Purity:	98% (HPLC)
Physical Form:	Pale yellow to yellow powder or solid
Melting Point:	119-123°C
Long-Term Storage:	Store long-term at 2-8°C
UN #:	UN2811
Hazard Class:	6.1
Packing Group:	III

BIOLOGICAL INFO
Application(s):	Calcium channel blocker
Form:	HCl salt

REVIEW
By deforming the channel, inhibiting ion-control gating mechanisms, and/or interfering with the release of calcium from the sarcoplasmic reticulum, Lercanidipine inhibits the influx of extracellular calcium across the myocardial and vascular smooth muscle cell membranes The decrease in intracellular calcium inhibits the contractile processes of the myocardial smooth muscle cells, causing dilation of the coronary and systemic arteries, increased oxygen delivery to the myocardial tissue, decreased total peripheral resistance, decreased systemic blood pressure, and decreased afterload.

REFERENCES

[1]	Lin TH, Voon WC, Yen HW, Huang CH, Su HM, Lai WT, Sheu SH: Lercanidipine and losartan effects on blood pressure and fibrinolytic parameters. Kaohsiung J Med Sci. 2006 Apr;22(4):177-83.
[2]	Martinez ML, Lopes LF, Coelho EB, Nobre F, Rocha JB, Gerlach RF, Tanus-Santos JE: Lercanidipine reduces matrix metalloproteinase-9 activity in patients with hypertension. J Cardiovasc Pharmacol. 2006 Jan;47(1):117-22.
[3]	Agrawal R, Marx A, Haller H: Efficacy and safety of lercanidipine versus hydrochlorothiazide as add-on to enalapril in diabetic populations with uncontrolled hypertension. J Hypertens. 2006 Jan;24(1):185-92.

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