REVIEW Vinorelbine tartrate, the orally available ditartrate salt of vinorelbine, a semisynthetic vinca alkaloid ) with antineoplastic activity derived from the leaves of the periwinkle plant (Vinca rosea. Vinorelbine binds to tubulin, inhibiting its polymerization into microtubules and spindle formation, resulting in apoptosis of susceptible cancer cells. Inhibition of mitotic microtubules correlates with vinorelbine's antitumor activity, whereas inhibition of axonal microtubules seems to correlate with its neurotoxicity. Compared to related vinca alkaloids, vinorelbine is more selective against mitotic than axonal microtubules in vitro, which may account for its decreased neurotoxicity. This agent is also a radiation-sensitizing agent.
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