[125317-39-7] Vinorelbine tartrate AKSci H847
 
 
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  H847    
Vinorelbine tartrate
, 98% (HPLC)
 



IDENTITY
CAS Number:[125317-39-7]
MDL Number:MFCD03613607
MF:C45H54N4O8.2C4H6O6
MW:1079.11
SPECIFICATIONS & PROPERTIES
Purity:98% (HPLC)
Available Spectra:NMR, LCMS, FT-IR, HPLC
Physical Form:Off-white to light orange crystalline powder
Melting Point:208-222°C (Anhyd.)
Long-Term Storage:Store long-term at -20°C
UN #:Not hazmat

REVIEW

 Vinorelbine tartrate, the orally available ditartrate salt of vinorelbine, a semisynthetic vinca alkaloid ) with antineoplastic activity derived from the leaves of the periwinkle plant (Vinca rosea. Vinorelbine binds to tubulin, inhibiting its polymerization into microtubules and spindle formation, resulting in apoptosis of susceptible cancer cells. Inhibition of mitotic microtubules correlates with vinorelbine's antitumor activity, whereas inhibition of axonal microtubules seems to correlate with its neurotoxicity. Compared to related vinca alkaloids, vinorelbine is more selective against mitotic than axonal microtubules in vitro, which may account for its decreased neurotoxicity. This agent is also a radiation-sensitizing agent.

REFERENCES
[1]Liu, Suyun; Que, Riming Synthesis of vinorelbine tartrate Zhongguo Yiyao Gongye Zazhi (2010), 41(9), 645-648.
[2] Moyano, Nora; Iturraspe, Jose; Nunez, Jose Lucio Process for the production of 5'-noranhydrovinblastine ditartrate from plants of genus Catharanthus Eur. Pat. Appl. (2001), EP 1118616 A1 20010725.
[3] Xu YC, Wang HX, Tang L, Ma Y, Zhang FC.A systematic review of vinorelbine for the treatment of breast cancer. Breast J. 2013 Mar-Apr;19(2):180-8.
[4] Marty M, Fumoleau P, Adenis A, Rousseau Y, Merrouche Y, Robinet G, Senac I, Puozzo C: Oral vinorelbine pharmacokinetics and absolute bioavailability study in patients with solid tumors. Ann Oncol. 2001 Nov;12(11):1643-9.

GHS

Pictograms

Signal Word
Warning

Hazard Statements
H317

Precautionary Statements
P261; P272; P280; P302+P352; P321; P333+P313; P363; P501


RELATED PRODUCTS
H847Vinorelbine tartrate
K210Vinorelbine

Current as of August 20, 2017


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CATEGORIES

 APIs and Bioactives > Alkaloids, Chemotherapeutics


PubChem