132112-35-7 (-)-Ropivacaine hydrochloride monohydrate AKSci H838
 
 
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  H838    AKSci Bulk Reagent
(-)-Ropivacaine hydrochloride monohydrate, 99% (HPLC)
 
(2S)-N-(2,6-dimethylphenyl)-1-propyl-2-piperidinecarboxamide monohydrochloride, LEA 103, (S)-Ropivacaine
IDENTITY
CAS Number:132112-35-7
MDL Number:MFCD00946578
MF:C17H26N2O.HCl.H2O
MW:328.88
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:99% (HPLC)
Physical Form (at 20°C):Solid
Melting Point:268-272°C
Optical Rotation:-6 ° ~ -10° (c=2, H2O)
Long-Term Storage:Store long-term at 2-8°C
DOT/IATA TRANSPORT INFORMATION
Not hazardous material

BIOLOGICAL INFO
Solubility:DMF: 15 mg/ml, DMSO: 25 mg/ml, Ethanol: 15 mg/ml, BS (pH 7.2): 0.25 mg/ml

REVIEW
 Local anesthetics such as Ropivacaine block the generation and the conduction of nerve impulses, presumably by increasing the threshold for electrical excitation in the nerve, by slowing the propagation of the nerve impulse, and by reducing the rate of rise of the action potential. Specifically, they block the sodium-channel and decrease chances of depolarization and consequent action potentials. In general, the progression of anesthesia is related to the diameter, myelination and conduction velocity of affected nerve fibers.

REFERENCES
[1]Weinberg G, Ripper R, Feinstein DL, Hoffman W: Lipid emulsion infusion rescues dogs from bupivacaine-induced cardiac toxicity. Reg Anesth Pain Med. 2003 May-Jun;28(3):198-202.
[2] Picard J, Meek T: Lipid emulsion to treat overdose of local anaesthetic: the gift of the glob. Anaesthesia. 2006 Feb;61(2):107-9.
[3] Rosenblatt MA, Abel M, Fischer GW, Itzkovich CJ, Eisenkraft JB: Successful use of a 20% lipid emulsion to resuscitate a patient after a presumed bupivacaine-related cardiac arrest. Anesthesiology. 2006 Jul;105(1):217-8.

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Danger

Hazard Statements
H318

Precautionary Statements
P280; P305+P351+P338; P310

RELATED PRODUCTS
H838(-)-Ropivacaine hydrochloride monohydrate
K500Ropivacaine

Current as of September 21, 2024


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CATEGORIES
 APIs and Bioactives > Anaesthetics


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