REVIEW Rifampicin S (also knows rifomycin S) is an ansamycin bactericidal antibiotic drug of the rifamycin group. It inhibits bacterial DNA-dependent RNA synthesis by inhibiting bacterial DNA-dependent RNA polymerase. Crystal structure data and biochemical data indicate that rifampicin S (and similar Rifampicin deriatives) binds to RNA polymerase at a site adjacent to the RNA polymerase active center and blocks RNA synthesis by physically preventing extension of RNA products beyond a length of 2-3 nucleotides (steric-occlusion mechanism). Rifampicin S (and the other Rifmapicins) are key components of anti-tuberculosis therapy .
REFERENCES
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Sensi, P.; Timbal, M. T.; Maffii, G Rifomycin. IX. Two new antibiotics of rifomycin family: rifomycin S and rifomycin SV. Preliminary report Experientia (1960), 16, 412.
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Sensi, P.; Ballotta, R.; Greco, A. M.; Gallo, G. G. Rifomycin. Activation of rifomycin B and rifomycin O. Production and properties of rifomycin S and rifomycin SV Farmaco, Edizione Scientifica (1961), 16, 165-80.
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Campbell EA, Korzheva N, Mustaev A, Murakami K, Nair S, Goldfarb A, Darst SA. Structural mechanism for rifampicin inhibition of bacterial RNA polymerase. Cell. 2001 Mar 23;104(6):901-12.
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Feklistov A, Mekler V, Jiang Q, Westblade LF, Irschik H, Jansen R, Mustaev A, Darst SA, Ebright RHRifamycins do not function by allosteric modulation of binding of Mg2+ to the RNA polymerase active center. Proc Natl Acad Sci U S A. 2008 Sep 30;105(39):14820-5.
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