13553-79-2 Rifampicin S AKSci H730
 
 
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  H730    AKSci Bulk Reagent
Rifampicin S
, 98%
 
Rifamycin S, 1,4-Dideoxy-1,4-dihydro-1,4-dioxorifamycin




IDENTITY
CAS Number:13553-79-2
MDL Number:MFCD06198807
MF:C37H45NO12
MW:695.75
EINECS:236-938-4
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:98%
Physical Form (at 20°C):Solid
Melting Point:179-181°C (dec.)
Optical Rotation:+476° (c=0.1, MeOH)
Long-Term Storage:Store long-term in a cool, dry place
DOT/IATA TRANSPORT INFORMATION
Not hazardous material

BIOLOGICAL INFO
Application(s):Semi-synthetic antibiotic

REVIEW

 Rifampicin S (also knows rifomycin S) is an ansamycin bactericidal antibiotic drug of the rifamycin group. It inhibits bacterial DNA-dependent RNA synthesis by inhibiting bacterial DNA-dependent RNA polymerase. Crystal structure data and biochemical data indicate that rifampicin S (and similar Rifampicin deriatives) binds to RNA polymerase at a site adjacent to the RNA polymerase active center and blocks RNA synthesis by physically preventing extension of RNA products beyond a length of 2-3 nucleotides (steric-occlusion mechanism). Rifampicin S (and the other Rifmapicins) are key components of anti-tuberculosis therapy .

REFERENCES
[1]Sensi, P.; Timbal, M. T.; Maffii, G Rifomycin. IX. Two new antibiotics of rifomycin family: rifomycin S and rifomycin SV. Preliminary report Experientia (1960), 16, 412.
[2] Sensi, P.; Ballotta, R.; Greco, A. M.; Gallo, G. G. Rifomycin. Activation of rifomycin B and rifomycin O. Production and properties of rifomycin S and rifomycin SV Farmaco, Edizione Scientifica (1961), 16, 165-80.
[3] Campbell EA, Korzheva N, Mustaev A, Murakami K, Nair S, Goldfarb A, Darst SA. Structural mechanism for rifampicin inhibition of bacterial RNA polymerase. Cell. 2001 Mar 23;104(6):901-12.
[4] Feklistov A, Mekler V, Jiang Q, Westblade LF, Irschik H, Jansen R, Mustaev A, Darst SA, Ebright RHRifamycins do not function by allosteric modulation of binding of Mg2+ to the RNA polymerase active center. Proc Natl Acad Sci U S A. 2008 Sep 30;105(39):14820-5.

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Warning

Hazard Statements
H315; H319; H335

Precautionary Statements
P261; P264; P271; P280; P302+P352; P304+P340; P305+P351+P338; P312; P321; P332+P313; P337+P313; P362; P403+P233; P405; P501


RELATED PRODUCTS
H731Rifampicin sodium, 900u/mg
H730Rifampicin S
M880Rifampicin

Current as of October 15, 2024


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CATEGORIES

 APIs and Bioactives > Antibacterials, Rifamycins


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