72217-12-0 2-(5-Amino-1,2,4-thiadiazol-3-yl)-2-(methoxyimino)acetic acid AKSci H595
 
 
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  H595    AKSci Bulk Reagent
2-(5-Amino-1,2,4-thiadiazol-3-yl)-2-(methoxyimino)acetic acid
, 98% (HPLC)
 



IDENTITY
CAS Number:72217-12-0
MDL Number:MFCD07782101
MF:C5H6N4O3S
MW:202.19
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:98% (HPLC)
Physical Form (at 20°C):Solid
Melting Point:179-183°C
Density:1.8
Refractive Index:1.74
Long-Term Storage:Store long-term in a cool, dry place
DOT/IATA TRANSPORT INFORMATION
Not hazardous material

REVIEW

 An advanced intermediate used in the preparation of side chains in beta-lactam cephalosporin and carbacephem antibiotics e.g. cefozopran.

REFERENCES
[1]Hashimoto, Masashi; Nakayama, Takarzuka; Hemmi, Keiji; Aratani, Matsuhiko; Takeno, Hidekazu; Hagiwara, Daijiro Cephalosporin analogs Ger. Offen. (1979), DE 2855418 A1 19790705.
[2] Teraji, Tsutomu; Sakane, Kazuo; Goto, Jiro 2-Substituted hydroxyimino-2-(5-amino-1,2,4-thiadiazol-3-yl)acetic acid or its salt and their intermediates Brit. UK Pat. Appl. (1982), GB 2094794 A 19820922.
[3] Teraji, Tsutomu; Sakane, Kazuo; Goto, Jiro 2-Substituted hydroxyimino-2-(5-amino-1,2,4-thiadiazol-3-yl)acetic acid or its salt and their intermediates Brit. UK Pat. Appl. (1982), GB 2094794 A 19820922.
[4] Kanai, Takeo; Takayanagi, Keizo; Tanaka, Yasuhide; Koiwa, Atsushi; Endo, Shinichi; Sato, Katsuhiko; Nomoto, Seiichiro; Sugiyama, Isao Preparation of 1,2,4-thiadiazolyl(alkoxyimino)acetic acids as intermediates for cephalosporins Jpn. Kokai Tokkyo Koho (1987), JP 62286979 A 19871212.

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Warning

Hazard Statements
H315; H319; H335

Precautionary Statements
P261; P264; P271; P280; P302+P352; P304+P340; P305+P351+P338; P312; P321; P332+P313; P337+P313; P362; P403+P233; P405; P501


RELATED PRODUCTS
H5952-(5-Amino-1,2,4-thiadiazol-3-yl)-2-(methoxyimino)acetic acid
X4778(Z)-2-(5-Amino-1,2,4-thiadiazol-3-yl)-2-(ethoxyimino)acetic acid

Current as of December 2, 2024


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CATEGORIES

 APIs and Bioactives > Cephalosporins
 Heterocyclic Building Blocks > Thiazoles, Carboxylic Acids, Amines, Ethers, Imine
 Heterocyclic Building Blocks > Thiazoles, Carboxylic Acids, Amines, Ethers, Imine


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