122883-93-6, 146939-27-7 Ziprasidone hydrochloride AKSci H485
 
 
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  H485    AKSci Reference Standard
Ziprasidone hydrochloride
, 99% (HPLC)
 
5-[2-[4-(1,2-Benzisothiazol-3yl)-1-piperazinyl]ethyl]-6-chloro-1,3-dihydro-2H-indol-2-one hydrochloride




IDENTITY
CAS Number:122883-93-6, 146939-27-7
MDL Number:MFCD06795476
MF:C21H22Cl2N4OS
MW:449.4
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:99% (HPLC)
Physical Form (at 20°C):Solid
Melting Point:295-300°C (dec.)
Long-Term Storage:Store long-term at -20°C
DOT/IATA TRANSPORT INFORMATION
Not hazardous material

BIOLOGICAL INFO
Form:Hydrochloride
Research Area:Neurological disease

REVIEW

 An atypical antipsychotic. Ziprasidone's affinities for most of the dopamine and serotonin receptors and the a1-adrenergic receptor are high and its affinity for the histamine H1 receptor is moderate.

REFERENCES
[1]Pappadopulos E, Newcomer JW, Kolluri S (2012). Changes in weight, plasma lipids, and glucose in adults treated with ziprasidone: a comprehensive analysis of pfizer-initiated clinical trials. J Clin Psychiatry. 73(6):e742-8. PMID 22795213.
[2] Park S, Kim MS, Namkoong C, Park MH, Hong JP (2012). The effect of ziprasidone on body weight and energy expenditure in female rats. Metabolism. 61(6):787-93. PMID 22209671.

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Warning

Hazard Statements
H315; H319; H335

Precautionary Statements
P261; P264; P271; P280; P302+P352; P304+P340; P305+P351+P338; P312; P321; P332+P313; P337+P313; P362; P403+P233; P405; P501


RELATED PRODUCTS
H485Ziprasidone hydrochloride
X9542Ziprasidone hydrochloride
E3992,3-Difluorobenzonitrile

Current as of October 2, 2022

AKSci Reference Standards are high-purity, low-impurity compounds suitable for use as standards.


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CATEGORIES

 APIs and Bioactives > Dopamine Antagonists, Antipsychotics


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